抗癌药物药物化学第二版 1849条(本栏目收费,不能显示细节,电话15274084725)
4.3. Carbohydrate Vaccines ..... 577 577
4.4. Peptide Vaccines ..... 579 579
4.5. Telomerase-Targeted Vaccines .... 581 581
4.6. Vaccines against Oncogenic Viruses .... 582 582
5. Gene Therapy .....582 582
GENERAL ASPECTS OF CANCER CHEMOTHERAPY ...1 1
1. Introduction: some general comments about cancer ...1 1
2. Tumorigenesis and oncogenes: pharmacogenomics ....2 2
3. Early diagnosis of cancer and its therapeutic relevance ...5 5
4. A brief history of cancer chemotherapy .....6 6
5. General comments about anticancer drug discovery ...8 8
6. Combination therapy and personalized anticancer treatments ...11 11
7. Natural products in cancer chemotherapy ....13 13
8. A brief comment about cancer nanotechnology ....14 14
9. Summary of FDA-approved anticancer drugs ....15 15
ANTIMETABOLITES THAT INTERFERE WITH NUCLEIC ACID BIOSYNTHESIS …24 24
1. Introduction .....24 24
2. Inhibitors of the biosynthesis of uridylic Acid ....25 25
11.2.2. Oxygen enhancement for radiosensitization ...181 181
11.2.3. Radioprotectors in radiotherapy ...182 182
DNA ALKYLATING AGENTS ...197 197
1. Introduction .....197 197
2. Nitrogen mustards ......198 198
2.1. Introduction ...... 198 198
2.2. DNA alkylation by nitrogen mustards and cytotoxicity mechanisms .. 200 200
2.3. Structure–activity relationships in nitrogen mustards .. 202 202
2.4. Site-directed nitrogen mustards .... 205 205
3. Aziridines (Ethyleneimines) .....212 212
4. Epoxides ......216 216