抗癌药物药物化学第二版 1849条(本栏目收费,不能显示细节,电话15274084725)
3.4. Monoclonal Antibodies ..... 517 517
4. Integrin Antagonists and Inhibitors of Chemokine Receptors ...517 517
5. Endogenous Inhibitors of Angiogenesis ....519 519
6. Miscellaneous Antiangiogenic Compounds ....522 522
6.1. Squalamine ..... 522 522
6.2. Thalidomide and Its Analogs ..... 522 522
6.3. Fumagillin Analogs .... 524 524
7. Drugs Targeting Cancer Stem Cells .....525 525
7.1. Wingless/β-Catenin Signaling .... 526 526
7.2. Inhibitors of the Notch Signaling Pathway .... 529 529
7.3. Hedgehog Signaling/Smo Receptor Inhibitors ... 531 531
7.4. Mesenchymal Stem Cell-Mediated Gene Therapy for Cancer .. 533 533
8. Inhibitors of Oncogenic Protein–Protein Interactions ....533 533
8.1. Anticancer Drugs Acting on Apoptotic Signaling Pathways ... 534 534
8.1.1. Programmed Cell Death and Its Relevance in Cancer .. 534 534
8.1.2. Apoptosis-Targeted Therapy: Death Receptor Ligands ... 539 539
8.1.3. Drugs Targeting the Bcl-2 Family of Proteins: BH3 Mimetics .. 539 539
BIOLOGICAL THERAPY OF CANCER ...561 561
1. Introduction .....561 561
2. Monoclonal Antibodies against Cancer Cells .....562 562
2.1. mAbs Targeting Specific Antigens ... 564 564
2.2. Specific Immunomodulatory mAbs .... 566 566
2.3. Bispecific Antibodies ..... 569 569
3. Cancer Immunotherapy: General Aspects .....570 570
3.1. Regulatory T Cells .... 571 571
3.2. Myeloid-Derived Suppressor Cells .... 572 572
3.3. Toll-like and NOD2 Receptors ..... 573 573
4. Cancer Vaccines ......575 575
4.1. Tumor Cell Vaccines and Vaccination Antigens ... 575 575
4.2. DNA and RNA Cancer Vaccines ..... 576 576