抗癌药物药物化学第二版 1849条(本栏目收费,不能显示细节,电话15274084725)
4.4. Pan-HER inhibitors .... 411 411
3. Inhibitors of ribonucleotide reductase .....26 26
3.1. Structure and catalytic cycle of ribonucleotide Reductase ... 26 26
3.2. Gallium salts and complexes .... 28 28
3.3. Radical scavengers .... 30 30
3.4. Substrate analogs as ribonucleotide reductase Inhibitors ... 31 31
3.5. Allosteric inhibition of ribonucleotide reductase via inhibition of purine nucleoside phosphorylase ..... 35 35
4. Inhibitors of the biosynthesis of thymidilic acid ...37 37
4.1. Thymidylate synthase ..... 37 37
4.2. 5-Fluorouracil and floxuridine ..... 38 38
4.3. 5-Fluorouracil prodrugs .... 41 41
4.4. Modulation of 5-Fluorouracil activity ... 45 45
4.4.1. Decreased degradation of 5-FU .... 45 45
4.4.2. Enhancement of the inhibition of thymidylate synthase by 5-FU ... 46 46
4.4.3. Enhancement of 5-FU activation ... 46 46
4.5. Trifluridine ...... 48 48
4.6. Folate-Based thymidylate synthase inhibitors ... 49 49
5. Inhibitors of dihydrofolate reductase .....54 54
5.1. Classical DHFR inhibitors ..... 56 56
5.2. Nonclassical (lipophilic) DHFR inhibitors ... 59 59
6. Inhibitors of the de novo purine biosynthesis pathway ....59 59
6.1. Inhibitors of PRPP amidotransferase ... 60 60
6.2. Inhibitors of glycinamide ribonucleotide formyltransferase .. 61 61
6.3. Inhibitors of phosphoribosylformylglycinamidine synthetase .. 62 62
6.4. Inhibitors of 5-Aminoimidazole-4-Carboxamide ribonucleotide formyltransferase . 65 65
6.5. Thiopurines and related compounds .... 65 65
7. Inhibitors of adenosine deaminase ....66 66
8. Inhibitors of late stages in DNA synthesis ....70 70
ANTICANCER DRUGS THAT MODULATE HORMONE ACTION...82 82
1. Introduction .....82 82