抗癌药物药物化学第二版 1849条(本栏目收费,不能显示细节,电话15274084725)
5. Methanesulfonates .....218 218
6. Nitrosoureas ......219 219
7. Triazenes .....225 225
8. Methylhydrazines .....227 227
9. 1,3,5-Triazines: hexamethylmelamine and trimelamol ....228 228
10. Transition metal species .....229 229
10.1. Platinum complexes ..... 229 229
10.2. Ruthenium complexes .... 236 236
10.3. Titanocenes .... 236 236
11. Miscellaneous alkylating and acylating antitumor agents ...237 237
References .......238 238
ANTICANCER DRUGS THAT INTERACT WITH THE DNA MINOR GROOVE..243 243
1. Introduction .....243 243
2. Netropsin, distamycin, and related compounds ....243 243
3. Mitomycins ......249 249
4. Tetrahydroisoquinoline alkaloids ....257 257
5. Cyclopropylindole alkylating agents ....264 264
6. Irofulven ......267 267
7. Pyrrolo[1,4]benzodiazepines ....268 268
References .......269 269
OTHER ANTICANCER DRUGS TARGETING DNA AND DNA-ASSOCIATED ENZYMES ...274 274
1. DNA intercalation and its consequences ....274 274
2. Small-Molecule Prodrugs for Anticancer Drug Targeting ...596 596
2.1. Selective Enzyme Expression in Tumor Cells .... 596 596
2.2. Hypoxia-Based Strategies for Tumor-Specific Prodrug Activation .. 598 598
2.2.1. N-Oxides ..... 599 599
2.2.2. Quinones ..... 600 600
2.2.3. Aromatic Nitro Derivatives .... 604 604
2.2.4. Cobalt Complexes ..... 608 608
2.2.5 Prodrugs Activated by Therapeutic Radiation .... 609 609