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抗癌药物药物化学第二版 1849条(本栏目收费,不能显示细节,电话13136136841)
4.3. Carbohydrate Vaccines ..... 577
577
4.4. Peptide Vaccines ..... 579
579
4.5. Telomerase-Targeted Vaccines .... 581
581
4.6. Vaccines against Oncogenic Viruses .... 582
582
5. Gene Therapy .....582
582
GENERAL ASPECTS OF CANCER CHEMOTHERAPY ...1
1
1. Introduction: some general comments about cancer ...1
1
2. Tumorigenesis and oncogenes: pharmacogenomics ....2
2
3. Early diagnosis of cancer and its therapeutic relevance ...5
5
4. A brief history of cancer chemotherapy .....6
6
5. General comments about anticancer drug discovery ...8
8
6. Combination therapy and personalized anticancer treatments ...11
11
7. Natural products in cancer chemotherapy ....13
13
8. A brief comment about cancer nanotechnology ....14
14
9. Summary of FDA-approved anticancer drugs ....15
15
ANTIMETABOLITES THAT INTERFERE WITH NUCLEIC ACID BIOSYNTHESIS …24
24
1. Introduction .....24
24
2. Inhibitors of the biosynthesis of uridylic Acid ....25
25
11.2.2. Oxygen enhancement for radiosensitization ...181
181
11.2.3. Radioprotectors in radiotherapy ...182
182
DNA ALKYLATING AGENTS ...197
197
1. Introduction .....197
197
2. Nitrogen mustards ......198
198
2.1. Introduction ...... 198
198
2.2. DNA alkylation by nitrogen mustards and cytotoxicity mechanisms .. 200
200
2.3. Structure–activity relationships in nitrogen mustards .. 202
202
2.4. Site-directed nitrogen mustards .... 205
205
3. Aziridines (Ethyleneimines) .....212
212
4. Epoxides ......216
216