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抗癌药物药物化学第二版 1849条(本栏目收费,不能显示细节,电话13136136841)
3.4. Monoclonal Antibodies ..... 517
517
4. Integrin Antagonists and Inhibitors of Chemokine Receptors ...517
517
5. Endogenous Inhibitors of Angiogenesis ....519
519
6. Miscellaneous Antiangiogenic Compounds ....522
522
6.1. Squalamine ..... 522
522
6.2. Thalidomide and Its Analogs ..... 522
522
6.3. Fumagillin Analogs .... 524
524
7. Drugs Targeting Cancer Stem Cells .....525
525
7.1. Wingless/β-Catenin Signaling .... 526
526
7.2. Inhibitors of the Notch Signaling Pathway .... 529
529
7.3. Hedgehog Signaling/Smo Receptor Inhibitors ... 531
531
7.4. Mesenchymal Stem Cell-Mediated Gene Therapy for Cancer .. 533
533
8. Inhibitors of Oncogenic Protein–Protein Interactions ....533
533
8.1. Anticancer Drugs Acting on Apoptotic Signaling Pathways ... 534
534
8.1.1. Programmed Cell Death and Its Relevance in Cancer .. 534
534
8.1.2. Apoptosis-Targeted Therapy: Death Receptor Ligands ... 539
539
8.1.3. Drugs Targeting the Bcl-2 Family of Proteins: BH3 Mimetics .. 539
539
BIOLOGICAL THERAPY OF CANCER ...561
561
1. Introduction .....561
561
2. Monoclonal Antibodies against Cancer Cells .....562
562
2.1. mAbs Targeting Specific Antigens ... 564
564
2.2. Specific Immunomodulatory mAbs .... 566
566
2.3. Bispecific Antibodies ..... 569
569
3. Cancer Immunotherapy: General Aspects .....570
570
3.1. Regulatory T Cells .... 571
571
3.2. Myeloid-Derived Suppressor Cells .... 572
572
3.3. Toll-like and NOD2 Receptors ..... 573
573
4. Cancer Vaccines ......575
575
4.1. Tumor Cell Vaccines and Vaccination Antigens ... 575
575
4.2. DNA and RNA Cancer Vaccines ..... 576
576