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抗癌药物药物化学第二版 1849条(本栏目收费,不能显示细节,电话13136136841)
2. Estrogens and their involvement in carcinogenesis ....82
82
3. Antiestrogens as antitumor drugs ....87
87
3.1. Nonsteroidal antiestrogens (selective estrogen receptor modulators) ... 87
87
3.2. Steroidal antiestrogens ..... 92
92
4. Aromatase inhibitors .....96
96
4.1. Aromatase mechanism of action .... 97
97
4.2. Steroidal aromatase inhibitors (type I inhibitors) ... 98
98
4.3. C-19 modified substrate analogs ..... 99
99
4.4. 4-Hydroxyandrostenedione derivatives ... 100
100
4.5. Steroids with additional unsaturations at the A and B rings ... 100
100
4.6. Structure–activity relationships in steroidal aromatase inhibitors .. 102
102
4.7. Nonsteroidal aromatase inhibitors (Type II) .... 102
102
Alkylphosphocholines, 449–451
449 451
Allogeneic vaccines, 577
577
Allopurinol, 66, 68f
66 68
All-trans retinoic acid (ATRA, tretinoin), 123, 125–126
123 125 126
Altretamine (hexamethylmelamine, Hexalen®), 228, 229f
228 229
3.4. Inhibitors of LIM kinase ..... 382
382
4. Miscellaneous anticancer drugs acting on novel sites of tubuline ...383
383
5. Antivascular effects of microtubule-targeted agents ...385
385
2.1.1. Proteasome Inhibitors in Cancer Therapy .... 496
496
2.1.2. NEDD8-Activating Enzyme Inhibitors ... 503
503
2.1.3. APC Inhibitors .... 505
505
2.2. Inhibitors of Matrix Metalloproteinases .... 508
508
2.3. Inhibitors of Aminopeptidases ..... 512
512
2.4. Inhibitors of Cathepsins ..... 512
512
3. Heparanase Inhibitors ......515
515
3.1. Polysaccharides with O- or N-Sulfate Groups .... 516
516
3.2. Compounds with C-Sulfonate Groups ... 516
516
3.3. Neutral Inhibitors .... 517
517