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抗癌药物药物化学第二版 1849条(本栏目收费,不能显示细节,电话13136136841)
7. Bleomycins ......161
161
8. Enediyne antibiotics .....165
165
9. Tirapazamine .....171
171
10. Penclomedine ......172
172
11. Radiotherapy and radiosensitizers .....173
173
11.1. Radiotherapy ..... 173
173
11.1.1. External beam radiotherapy ...175
175
11.1.2. Brachytherapy (internal radiation therapy) ..175
175
11.1.3. Radioisotope therapy ....175
175
11.1.4. Neutron irradiation .....178
178
11.2. Drugs Used to improve the results of radiotherapy .. 179
179
11.2.1. Radiosensitizers ....179
179
2. Monofunctional intercalating agents .....276
276
2.1. Ellipticine and its analogs .... 276
276
2.2. Actinomycins ...... 279
279
2.3. Fused quinolines ..... 280
280
2.4. Naphthalimides and related compounds .... 281
281
2.5. Chartreusin, elsamicin A, and related compounds ... 281
281
6. Mitotic kinesin inhibitors ......386
386
References .......387
387
DRUGS THAT INHIBIT SIGNALING PATHWAYS FOR TUMOR CELL GROWTH AND PROLIFERATION...392
392
1. Introduction .....392
392
2. Oncogenes and signal transduction .....393
393
3. The role of protein kinases in cancer: signaling pathways related to kinases ..394
394
4. Inhibitors of tyrosine kinases ....402
402
4.1. Inhibitors of EGFR (HER-1) .... 403
403
4.1.1. Small-molecule EGFR inhibitors ...405
405
4.1.2. Monoclonal antibodies acting as inhibitors of EGFR ...409
409
4.2. Inhibitors of HER-2 .... 410
410
4.3. Inhibitors of HER-3 .... 411
411