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 抗癌药物药物化学第二版 1849条(本栏目收费,不能显示细节,电话15274084725)
5. Steroid sulfatase inhibitors .....105 105
6. Androgen-related antitumor agents ....105 105
6.1. Antiandrogens ..... 107 107
6.1.1. Steroidal antiandrogens ....107 107
6.1.2. Nonsteroidal antiandrogens ....108 108
6.2. Inhibitors of androgen biosynthesis ... 110 110
6.2.1. Inhibitors of 14α-demethylase ...111 111
6.2.2. Inhibitors of CYP17A1 (17α-hydroxylase and C(17,20)-lyase) ..112 112
6.2.3. Inhibitors of 5α-reductase ...115 115
7. Regulation of gonadotropin-releasing hormone: control of the hypothalamic–pituitary–gonadal ...116 116
7.1. Introduction ...... 116 116
7.2. GnRH (LHRH) agonists .... 118 118
7.3. GnRH (LHRH) antagonists .... 118 118
8. Miscellaneous steroid hormone-related anticancer therapy ...121 121
8.1. Gestagens as antitumor agents .... 121 121
8.2. Glucocorticoids and inhibitors of their biosynthesis as antitumor agents . 122 122
ANTICANCER DRUGS ACTING VIA RADICAL SPECIES ...134 134
1. Introduction: radicals and other reactive oxygen species ....134 134
2. Biological effects of reactive oxygen species ...135 135
2.1. Membrane phospholipid peroxidation .... 136 136
2.2. Malondialdehyde generation and its consequences ... 137 137
2.3. DNA strand cleavage .... 139 139
2.4. Oxidation of DNA bases .... 142 142
2.5. Formaldehyde generation .... 145 145
2.6. ROS as signaling molecules .... 145 145
2.7. Oxidative stress induction as a strategy in cancer treatment .. 145 145
3. Anthracyclines and their analogs ....146 146
4. Mitoxantrone and related quinones ....156 156
5. Actinomycin D ......159 159
6. Chartreusin, elsamicin A, and related compounds ....160 160
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