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抗癌药物药物化学第二版 1849条(本栏目收费,不能显示细节,电话13136136841)
5. Steroid sulfatase inhibitors .....105
105
6. Androgen-related antitumor agents ....105
105
6.1. Antiandrogens ..... 107
107
6.1.1. Steroidal antiandrogens ....107
107
6.1.2. Nonsteroidal antiandrogens ....108
108
6.2. Inhibitors of androgen biosynthesis ... 110
110
6.2.1. Inhibitors of 14α-demethylase ...111
111
6.2.2. Inhibitors of CYP17A1 (17α-hydroxylase and C(17,20)-lyase) ..112
112
6.2.3. Inhibitors of 5α-reductase ...115
115
7. Regulation of gonadotropin-releasing hormone: control of the hypothalamic–pituitary–gonadal ...116
116
7.1. Introduction ...... 116
116
7.2. GnRH (LHRH) agonists .... 118
118
7.3. GnRH (LHRH) antagonists .... 118
118
8. Miscellaneous steroid hormone-related anticancer therapy ...121
121
8.1. Gestagens as antitumor agents .... 121
121
8.2. Glucocorticoids and inhibitors of their biosynthesis as antitumor agents . 122
122
ANTICANCER DRUGS ACTING VIA RADICAL SPECIES ...134
134
1. Introduction: radicals and other reactive oxygen species ....134
134
2. Biological effects of reactive oxygen species ...135
135
2.1. Membrane phospholipid peroxidation .... 136
136
2.2. Malondialdehyde generation and its consequences ... 137
137
2.3. DNA strand cleavage .... 139
139
2.4. Oxidation of DNA bases .... 142
142
2.5. Formaldehyde generation .... 145
145
2.6. ROS as signaling molecules .... 145
145
2.7. Oxidative stress induction as a strategy in cancer treatment .. 145
145
3. Anthracyclines and their analogs ....146
146
4. Mitoxantrone and related quinones ....156
156
5. Actinomycin D ......159
159
6. Chartreusin, elsamicin A, and related compounds ....160
160