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药物发现的新方法 872条(本栏目收费,不能显示细节,电话13136136841)
concentration–time profile, 244
244
target validation, 239
239
therapeutic window, 253–254
253 254
PH Groups 1 (PAH), 228, 229
228 229
Phosphatases, 46–48
46 48
Phospholipidosis, 275
275
Phototoxicity, 274–275
274 275
Physiologically based PK (PBPK) model, 246,316–318
246 316 318
Pitstops 1 and 4, 130, 131
130 131
PK. See Pharmacokinetics (PK)
PKS. See Polyketide synthetases (PKS)
Plants, natural products, 94–95
94 95
Plate-based screening, 34
34
Polyketide synthetases (PKS), 105, 106
105 106
Positional-scanning synthetic-peptide combinatorial library (PS-SPCL),77–78
77 78
PPIs. See Protein–protein interactions (PPIs)
PRA. See Progesterone receptor antagonists (PRA) Pravastatin, 95, 96
95 96
Preclinical animal models, 66–67
66 67
Preclinical oncology 2D cell cultures, 215
215
drug discovery process, 204, 205
204 205
humanized mice model, 211
211
lead identification and optimization
mouse and rat strains, 209–211
209 211