药物发现的新方法 872条(本栏目收费,不能显示细节,电话15274084725)
PBPK model. See Physiologically based PK (PBPK) model 0
PDB. See Protein databank (PDB) 0
PDX models. See Patient-derived xenograft (PDX) models Penicillin, 6–8 8
Penicillium chrysogenum, 92 92
PGR. See Progesterone receptors (PGR) 0
PGR modulator-associated endometrial change (PAEC), 196 196
PH. See Pulmonary hypertension (PH) Pharmaceutical drug discovery biological big data, 26 26
CRISPR/Cas9 target screening, 36–38 38
addressing off-target effects, 34–36 36
arrayed screens transfect siRNAs, 30 30
3D tumor spheroids, 31, 32 32
homogenous assays, 30–31 31
plate-based screening, 34 34
synthetic lethality, 33 33
Pharmacodynamic (PD) biomarkers, 231 231
DMPK-related development risks, 254–255 255
dose prediction, 251–253 253
methyl-lysine/arginine reader domains,53, 54 54
physiological regulation, 127 127