药物发现的新方法 872条(本栏目收费,不能显示细节,电话15274084725)
Research use only (RUO) assay, 307 307
Right ventricular systolic pressure (RVSP),229 229
RNAi. See Interference RNA (RNAi) 0
RNA interference (RNAi) addressing off-target effects, 34–36 36
screening technologies, 30–32 32
plate-based screening, assay performance, hit identification, and statistics, 34 34
synthetic lethality, 33 33
Ro5. See Rule of 5 (Ro5) RO2443, 132, 133 133
Routine cell culture, 175–176 176
RUO assay. See Research use only (RUO) 0
rWEC. See Rat whole embryonic cell culture 0
Safety screening, 264, 269 269
Salmonella typhimurium, 265 265
Sampson hypothesis endometriosis, 197 197
SAR. See Structure–activity relationships (SAR) Scaffold hopping, 150, 159–162 162
Second mitochondrial activator of caspase (SMAC), 128 128
Serum creatinine (SCr), 290 290
sGC stimulator. See Soluble guanylate cyclase (sGC) stimulator shRNA dropout screening, 33 33
Thienodiazepine-type BET inhibitors, 51 51