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药物发现的新方法 872条(本栏目收费,不能显示细节,电话13136136841)
Research use only (RUO) assay, 307
307
Right ventricular systolic pressure (RVSP),229
229
RNAi. See Interference RNA (RNAi)
RNA interference (RNAi) addressing off-target effects, 34–36
34 36
screening technologies, 30–32
30 32
plate-based screening, assay performance, hit identification, and statistics, 34
34
synthetic lethality, 33
33
Ro5. See Rule of 5 (Ro5) RO2443, 132, 133
132 133
Routine cell culture, 175–176
175 176
RUO assay. See Research use only (RUO)
rWEC. See Rat whole embryonic cell culture
Safety screening, 264, 269
264 269
Salmonella typhimurium, 265
265
Sampson hypothesis endometriosis, 197
197
SAR. See Structure–activity relationships (SAR) Scaffold hopping, 150, 159–162
150 159 162
Second mitochondrial activator of caspase (SMAC), 128
128
Serum creatinine (SCr), 290
290
sGC stimulator. See Soluble guanylate cyclase (sGC) stimulator shRNA dropout screening, 33
33
Thienodiazepine-type BET inhibitors, 51
51