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药物发现的新方法 872条(本栏目收费,不能显示细节,电话13136136841)
Target identification and validation (TIV),204–206
204 206
Target-oriented high-throughput synthesis (TOS), 85, 86
85 86
Target validation biologic approaches, 64–65
64 65
genetic approaches, 65
65
ideal animal disease model, 60
60
mammalian models GEMMs, 61–62
61 62
larger disease animal models, 63
63
wild-type mice, 60–61
60 61
Caenorhabditis elegans, 63–64
63 64
preclinical animal models, translatability of, 66–67
66 67
Teicoplanin, 96, 97
96 97
Terrestrial fungi, natural products, 95, 96
95 96
Thermodynamic aqueous solubility assays, 154
154
QSPR models. See Quantitative structure–property relationship (QSPR) models Quantitative structure–property relationship (QSPR) models, 148, 157–159
148 157 159
Quinazolinone privileged scaffold, 52, 114
52 114
direct targeting strategies for, 49
49
Rat whole embryonic cell culture (rWEC), 273
273
Recombinant proteins, 64
64
Reliable test systems, 173–175
173 175
Renilla luciferase, 182
182
Renin inhibitor aliskiren, 11
11
Reporter gene assays, 181
181