药物发现的新方法 872条(本栏目收费,不能显示细节,电话15274084725)
Target identification and validation (TIV),204–206 206
Target-oriented high-throughput synthesis (TOS), 85, 86 86
Target validation biologic approaches, 64–65 65
genetic approaches, 65 65
ideal animal disease model, 60 60
mammalian models GEMMs, 61–62 62
larger disease animal models, 63 63
Caenorhabditis elegans, 63–64 64
preclinical animal models, translatability of, 66–67 67
Terrestrial fungi, natural products, 95, 96 96
Thermodynamic aqueous solubility assays, 154 154
QSPR models. See Quantitative structure–property relationship (QSPR) models Quantitative structure–property relationship (QSPR) models, 148, 157–159 159
Quinazolinone privileged scaffold, 52, 114 114
direct targeting strategies for, 49 49
Rat whole embryonic cell culture (rWEC), 273 273
Recombinant proteins, 64 64
Reliable test systems, 173–175 175
Renilla luciferase, 182 182
Renin inhibitor aliskiren, 11 11
Reporter gene assays, 181 181