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抗癌药物药物化学第二版 1849条(本栏目收费,不能显示细节,电话13136136841)
5. Methanesulfonates .....218
218
6. Nitrosoureas ......219
219
7. Triazenes .....225
225
8. Methylhydrazines .....227
227
9. 1,3,5-Triazines: hexamethylmelamine and trimelamol ....228
228
10. Transition metal species .....229
229
10.1. Platinum complexes ..... 229
229
10.2. Ruthenium complexes .... 236
236
10.3. Titanocenes .... 236
236
11. Miscellaneous alkylating and acylating antitumor agents ...237
237
References .......238
238
ANTICANCER DRUGS THAT INTERACT WITH THE DNA MINOR GROOVE..243
243
1. Introduction .....243
243
2. Netropsin, distamycin, and related compounds ....243
243
3. Mitomycins ......249
249
4. Tetrahydroisoquinoline alkaloids ....257
257
5. Cyclopropylindole alkylating agents ....264
264
6. Irofulven ......267
267
7. Pyrrolo[1,4]benzodiazepines ....268
268
References .......269
269
OTHER ANTICANCER DRUGS TARGETING DNA AND DNA-ASSOCIATED ENZYMES ...274
274
1. DNA intercalation and its consequences ....274
274
2. Small-Molecule Prodrugs for Anticancer Drug Targeting ...596
596
2.1. Selective Enzyme Expression in Tumor Cells .... 596
596
2.2. Hypoxia-Based Strategies for Tumor-Specific Prodrug Activation .. 598
598
2.2.1. N-Oxides ..... 599
599
2.2.2. Quinones ..... 600
600
2.2.3. Aromatic Nitro Derivatives .... 604
604
2.2.4. Cobalt Complexes ..... 608
608
2.2.5 Prodrugs Activated by Therapeutic Radiation .... 609
609