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药物发现的新方法 872条(本栏目收费,不能显示细节,电话13136136841)
PBPK model. See Physiologically based PK (PBPK) model
PDB. See Protein databank (PDB)
PDX models. See Patient-derived xenograft (PDX) models Penicillin, 6–8
6 8
Penicillium chrysogenum, 92
92
PGR. See Progesterone receptors (PGR)
PGR modulator-associated endometrial change (PAEC), 196
196
PH. See Pulmonary hypertension (PH) Pharmaceutical drug discovery biological big data, 26
26
CRISPR/Cas9 target screening, 36–38
36 38
addressing off-target effects, 34–36
34 36
arrayed screens transfect siRNAs, 30
30
3D tumor spheroids, 31, 32
31 32
homogenous assays, 30–31
30 31
plate-based screening, 34
34
synthetic lethality, 33
33
Pharmacodynamic (PD) biomarkers, 231
231
DMPK-related development risks, 254–255
254 255
dose prediction, 251–253
251 253
methyl-lysine/arginine reader domains,53, 54
53 54
physiological regulation, 127
127