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抗癌药物药物化学第二版 1849条(本栏目收费,不能显示细节,电话13136136841)
3.2.2. Irreversible inhibitors of glutathione S-transferase ... 672
672
Alvocidib (flavopiridol), 435, 436f
435 436
9-Aminocamptothecin, 294
294
5-Aminolevulinic acid (ALA, Levulan®), 187, 187f, 709
187 187 709
Aminopeptidase N (APN, CD13), 514
514
Aminopeptidase N (CD13), 645
645
2.6. Other monofunctional intercalating agents ... 282
282
3. Bifunctional intercalating agents .....282
282
4. Indirect DNA damage by DNA topoisomerase inhibitors ...285
285
4.1. Topoisomerase I mechanism ..... 285
285
4.2. Topoisomerase II mechanism .... 286
286
5. Specific topoisomerase I inhibitors .....290
290
5.1. Camptothecins .... 290
290
5.2. Non-camptothecin topoisomerase I inhibitors ... 298
298
6. Topoisomerase II poisons .....301
301
6.1. Acridine derivatives .... 301
301
6.2. Anthracyclines and related compounds .... 302
302
6.3. Non-intercalating topoisomerase II poisons .... 305
305
6.3.1. Etoposide and its analogs .... 305
305
6.3.2. Salvicine .... 308
308
7. Topoisomerase II catalytic inhibitors .....309
309
7.1. Inhibitors of the binding of topoisomerase II to DNA ... 309
309
7.1.1. Aclarubicin .... 309
309
7.1.2. Merbarone ..... 310
310
7.1.3. Bis(dioxopiperazines) .... 310
310
8. Telomerase inhibitors and other anticancer approaches targeting telomeres ...311
311