adenosine 3',5'-bisphosphate
IUPAC 名称
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}phosphonic acid
描述
Adenosine-3'-5'-diphosphate, also known as 3'-phosphoadenylate or pap, is a member of the class of compounds known as purine ribonucleoside 3',5'-bisphosphates. Purine ribonucleoside 3',5'-bisphosphates are purine ribobucleotides with one phosphate group attached to 3' and 5' hydroxyl groups of the ribose moiety. Adenosine-3'-5'-diphosphate is slightly soluble (in water) and an extremely strong acidic compound (based on its pKa). Adenosine-3'-5'-diphosphate can be found in a number of food items such as beech nut, canola, chickpea, and red algae, which makes adenosine-3'-5'-diphosphate a potential biomarker for the consumption of these food products. Adenosine-3'-5'-diphosphate can be found primarily in cellular cytoplasm, as well as in human brain and liver tissues. Adenosine-3'-5'-diphosphate exists in all living species, ranging from bacteria to humans. In humans, adenosine-3'-5'-diphosphate is involved in several metabolic pathways, some of which include acetaminophen metabolism pathway, tamoxifen action pathway, androgen and estrogen metabolism, and metachromatic leukodystrophy (MLD). Adenosine-3'-5'-diphosphate is also involved in several metabolic disorders, some of which include gaucher disease, krabbe disease, fabry disease, and 17-beta hydroxysteroid dehydrogenase III deficiency.
异构
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]1O
InChI标识符
InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/t4-,6-,7-,10-/m1/s1
键
WHTCPDAXWFLDIH-KQYNXXCUSA-N