5b-Pregnanediol
IUPAC 名称
14-ethyl-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecane
描述
5beta-Pregnanediol is an endogenous human metabolite of testosterone. The 5beta-Pregnanediol excretion is low in women with suspected placental insufficiency and in women with uterine fibroma. 5beta-Pregnanediol levels can change in endocrine disturbances such as hirsutism or Cushing's syndrome, depending on the stage of the disease. 5beta-Pregnanediol has been tried as a more reliable compound to measure in screening of urinary steroids when suspecting doping, due to its not significant isotopic fractionation that could lead to false positive results in anti-doping testing. 13C-enrichment caused by a diet change might be a reason of concern in athletes that move around between places and might have a considerable change of diet between competitions. In contrast to the results obtained with the carbon isotopic ratio, profiling of urinary testosterone/epitestosterone (T/E) ratios is found to be unaffected by a diet change. (PMID: 16338181, 5172227, 13636945, 14440289) [HMDB]
异构
CCC1CCC2C3CCC4CCCCC4(C)C3CCC12C
InChI标识符
InChI=1S/C21H36/c1-4-15-9-11-18-17-10-8-16-7-5-6-13-20(16,2)19(17)12-14-21(15,18)3/h15-19H,4-14H2,1-3H3
键
JWMFYGXQPXQEEM-UHFFFAOYSA-N