8-iso-15-keto-PGF2a
IUPAC 名称
7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-(3-oxooct-1-en-1-yl)cyclopentyl]hept-5-enoic acid
描述
8-iso-15-keto-PGF2alpha is an isoprostane. Isoprostanes are produced during peroxidation of membrane lipids by free radicals and reactive oxygen species, and are currently used as markers of many disease states and experimental conditions in which oxidative stress is a prominent feature. A small number of reports have described the ability of some isoprostanes to evoke important biological effects in smooth muscle and other cell types. There is a long (and growing) list of disease states and pathophysiological conditions which are associated with marked elevation in the levels of iso- prostanes. For example, measured levels of the plasma, urine, bronchoalveolar lavage fluid, and/or tissues of smokers, patients with asthma chronic obstructive pulmonary disease, interstitial lung disease, cystic fibrosis, or acute chest syndrome, during exposure to allergen, ozone or hyperoxia; and during ventilated ischemia. Likewise, cardiovascular conditions such as renal, myocardial, ischemia-reperfusion injury, atherosclerosis, and pre-eclampsia are also indicated by a marked elevation of plasma/urinary levels of isoprostanes. (PMID: 10930353) [HMDB]
异构
[H][C@]1(O)C[C@@]([H])(O)[C@]([H])(C=CC(=O)CCCCC)[C@]1([H])CC=CCCCC(O)=O
InChI标识符
InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,16-19,22-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/t16-,17+,18-,19+/m0/s1
键
LOLJEILMPWPILA-ZSYWTGECSA-N