1,3,7,9-Tetramethyluric acid
IUPAC 名称
tetramethyl-2,3,6,7,8,9-hexahydro-1H-purine-2,6,8-trione
描述
Isolated from tea
Temurin is a methyl derivative of uric acid, found occasionally in human urine. Temurin is one of the purine components in urinary calculi. Methylated purines originate from the metabolism of methylxanthines (caffeine, theophylline and theobromine). Methyluric acids are indistinguishable from uric acid by simple methods routinely used in clinical laboratories, requiring the use of high-performance liquid chromatography (HPLC). Purine derivatives in urinary calculi could be considered markers of abnormal purine metabolism. The content of a purine derivative in stone depends on its average urinary excretion in the general population, similarity to the chemical structure of uric acid, and content of the latter in stone. This suggests that purines in stones represent a solid solution with uric acid as solvent. It is also plausible that methylxanthines, ubiquitous components of the diet and drugs, are involved in the pathogenesis of urolithiasis. (PMID: 11712316, 15833286, 3506820, 15013152). 1,3,7,9-Tetramethyluric acid is found in cupuaçu and tea.
异构
CN1C(=O)N(C)C2=C1N(C)C(=O)N(C)C2=O
InChI标识符
InChI=1S/C9H12N4O3/c1-10-5-6(11(2)8(10)15)12(3)9(16)13(4)7(5)14/h1-4H3
键
QGDOQULISIQFHQ-UHFFFAOYSA-N