1,2-Dibromo-3-chloropropane
描述
1,2-Dibromo-3-chloropropane is a manufactured chemical and the active ingredient in the nematicide Nemagon, also known as Fumazone. Nemagon is a soil fumigant formerly used in agriculture but banned to most areas today. (L126)
类别
"Pesticide", "Pollutant", "Airborne Pollutant", "Synthetic Toxin"
同义词
"1,2-Dibromo-3-chloropropane (DBCP)", "1,2-Dibromochloropropane", "1,3-Dibromo-3-chloropropane", "1-Chloro-2,3-dibromopropane", "2,3-Dibromo-1-chloropropane", "3-Chloro-1,2-dibromopropane", "Fumagon", "Fumazone", "Gro-tone nematode granular", "Nemabrom", "Nemafume", "Nemagon", "Nemagon soil fumigant", "Nemagone", "Nemanax", "Nemanex", "Nemapaz", "Nemaset", "Nematocide", "Nematox", "Nemazon"
IUPAC 名称
1,2-dibromo-3-chloropropane
传统名称
1,2-dibromo-3-chloropropane
InChI 标识符
InChI=1/C3H5Br2Cl/c4-1-3(5)2-6/h3H,1-2H2
键
InChIKey=WBEJYOJJBDISQU-UHFFFAOYNA-N
大分类
Organohalogen compounds
另外分类
"Alkyl bromides", "Alkyl chlorides", "Hydrocarbon derivatives", "Organobromides"
取代基
"Aliphatic acyclic compound", "Alkyl bromide", "Alkyl chloride", "Alkyl halide", "Hydrocarbon derivative", "Organobromide", "Organochloride"
分子框架
Aliphatic acyclic compounds
外部描述符
"organochlorine compound"
地位
Detected and Not Quantified
蜂窝位置
"Cytosol", "Membrane", "Microsome", "Mitochondrion"
熔点/沸点/溶解度
6°C//1.23 mg/mL at 20 °C [MUNNECKE,DE & VANGUNDY,SD (1979)]
暴露途径
Oral (L125) ; inhalation (L125) ; dermal (L125)
毒性机制
The initial metabolism of 1,2-dibromo-3-chloropropane to reactive epoxide metabolites that bind to DNA and other macromolecules may be responsible for its hepatotoxicity and nephrotoxicity. The mechanism of 1,2-dibromo-3-chloropropane's testicular toxicity is believed to be due to either the inhibition of sperm carbohydrate metabolism, probably at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain, or drect DNA damage caused by its metabolites. (L125, A13)
代谢
1,2-Dibromo-3-chloropropane is absorbed via oral, inhalation, and dermal routes. It accumulates mainly in the kidney, liver, and adipose tissues. 1,2-Dibromo-3-chloropropane is intially converted to epoxy derivatives, which are
further hydrolyzed and debrominated. Glutathione (GSH) conjugation of epoxide intermediates in the liver is believed to produce precursors to toxic intermediates. The metabolites are excreted mainly in the urine. (L125)
毒性值
LD50: 100 mg/kg (Oral, Rabbit) (T25)
LC50: 1480 mg/m3 over 1 hour (Inhalation, Rat) (T25)
致癌性
2B, possibly carcinogenic to humans. (L135)
用途/来源
1,2-Dibromo-3-chloropropane is the active ingredient in the nematicide Nemagon, also known as Fumazone. Nemagon is a soil fumigant formerly used in agriculture. (L125)
最低风险等级
Intermediate Inhalation: 0.0002 ppm (L134)
Intermediate Oral: 0.002 mg/kg/day (L134)
健康影响
Breathing high levels of 1,2-dibromo-3-chloropropane causes reproductive damage, including reduced sperm counts, birth defects, and infertility. It may also damage the stomach, liver, kidneys, brain, spleen, blood, and lungs, and cause skin and eye damage from direct contact. (L125)
症状
Symptoms of 1,2-dibromo-3-chloropropane exposure include headaches, nausea, lightheadedness, and weakness. (L125)
治疗
EYES: irrigate opened eyes for several minutes under running water.
INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice.
SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention.
INHALATION: supply fresh air. If required provide artificial respiration.
维基百科链接
http://en.wikipedia.org/wiki/1,2-Dibromo-3-chloropropane
创建于
2009-03-06 18:57:58 UTC
更新于
2014-12-24 20:20:57 UTC
目标
| 毒素T3DB ID | 毒素名称 | 目标名称 |
|---|
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Estrogen receptor beta |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Estrogen receptor alpha |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Sodium/potassium-transporting ATPase subunit beta-3 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Sodium/potassium-transporting ATPase subunit beta-2 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Sodium/potassium-transporting ATPase subunit beta-1 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Sodium/potassium-transporting ATPase subunit alpha-4 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Sodium/potassium-transporting ATPase subunit alpha-3 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Sodium/potassium-transporting ATPase subunit alpha-2 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Sodium/potassium-transporting ATPase subunit alpha-1 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Sodium/potassium-transporting ATPase subunit gamma |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Plasma membrane calcium-transporting ATPase 4 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Plasma membrane calcium-transporting ATPase 3 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Plasma membrane calcium-transporting ATPase 2 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Plasma membrane calcium-transporting ATPase 1 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Gamma-aminobutyric acid receptor subunit theta |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Gamma-aminobutyric acid receptor subunit rho-3 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Gamma-aminobutyric acid receptor subunit rho-2 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Gamma-aminobutyric acid receptor subunit rho-1 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Gamma-aminobutyric acid receptor subunit pi |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Gamma-aminobutyric acid receptor subunit gamma-3 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Gamma-aminobutyric acid receptor subunit gamma-1 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Gamma-aminobutyric acid receptor subunit epsilon |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Gamma-aminobutyric acid receptor subunit delta |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Gamma-aminobutyric acid receptor subunit beta-2 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Gamma-aminobutyric acid receptor subunit beta-1 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Gamma-aminobutyric acid receptor subunit alpha-6 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Gamma-aminobutyric acid receptor subunit alpha-5 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Gamma-aminobutyric acid receptor subunit alpha-4 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Gamma-aminobutyric acid receptor subunit alpha-3 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Gamma-aminobutyric acid receptor subunit alpha-2 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Calcium-transporting ATPase type 2C member 2 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
Calcium-transporting ATPase type 2C member 1 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
DNA |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH-ubiquinone oxidoreductase chain 6 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH-ubiquinone oxidoreductase chain 5 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH-ubiquinone oxidoreductase chain 4L |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH-ubiquinone oxidoreductase chain 4 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH-ubiquinone oxidoreductase chain 3 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH-ubiquinone oxidoreductase chain 2 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH-ubiquinone oxidoreductase chain 1 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial |
| T3D0044 |
1,2-Dibromo-3-chloropropane |
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial |