毒素T3DB ID

T3D0044

目标BioDB ID

BE0004796

目标名称

DNA

目标UniProt ID

作用机理

The initial metabolism of 1,2-dibromo-3-chloropropane to reactive epoxide metabolites that bind to DNA and other macromolecules may be responsible for its hepatotoxicity and nephrotoxicity. The mechanism of 1,2-dibromo-3-chloropropane's testicular toxicity is believed to be due to either the inhibition of sperm carbohydrate metabolism, probably at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain, or drect DNA damage caused by its metabolites. (L125)

参考文献

A13 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. (3672526) L125 - ATSDR - Agency for Toxic Substances and Disease Registry (1992). Toxicological profile for 1,2-dibromo-3-chloropropane. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). (http://www.atsdr.cdc.gov/toxprofiles/tp36.html)

创建于

2009-05-26 20:16:34 UTC

更新于

2014-09-29 19:30:35 UTC