描述
3,3'-Dichlorobenzidine is a manufactured chemical used in pigments for printing inks, textiles, plastics and enamels, paint, leather, and rubber. (L124)
同义词
"3, 3'-Dichlorobenzidine", "3,3 Dichlorobenzidine", "3,3' Dichlorobenzidine", "3,3'-dichloro-(1,1'-Biphenyl)-4,4'-diamine", "3,3'-Dichloro-4, 4'-diaminodiphenyl", "3,3'-Dichloro-4,4'-biphenyldiamine", "3,3'-Dichloro-4,4'-diamino(1,1-biphenyl)", "3,3'-Dichloro-4,4'-diaminobiphenyl", "3,3'-dichloro-Benzidine", "3,3'-Dichloro-p,p'-bianiline", "3,3'-Dichlorobiphenyl-4,4'-diamine", "3,3'-dichlorobiphenyl-4,4'-ylenediamine", "3,3'-dichloro[1,1'-biphenyl]-4,4'-diamine", "3,3-Dichloro-[1,1]-biphenyl-4,4-diamine", "3,3-Dichlorobenzidine", "4'-Amino-3,3'-dichloro(1,1'-biphenyl)-4-ylamine", "4'-Amino-3,3'-dichloro[1,1'-biphenyl]-4-ylamine", "4,4'-Diamino-3,3'-dichlorodiphenyl", "4,4'Ddiamino-3,3'-dichlorobiphenyl", "Dichlorobenzidine", "o,o'-dichlorobenzidine", "Ortho,ortho'-dichlorobenzidine"
另外分类
"Aniline and substituted anilines", "Aryl chlorides", "Chlorobenzenes", "Hydrocarbon derivatives", "Organochlorides", "Organopnictogen compounds", "Polychlorinated biphenyls", "Primary amines"
取代基
"3,3'-disubstituted benzidine", "Amine", "Aniline or substituted anilines", "Aromatic homomonocyclic compound", "Aryl chloride", "Aryl halide", "Chlorinated biphenyl", "Chlorobenzene", "Halobenzene", "Hydrocarbon derivative", "Organic nitrogen compound", "Organochloride", "Organohalogen compound", "Organonitrogen compound", "Organopnictogen compound", "Polychlorinated biphenyl", "Primary amine"
毒性机制
3,3’-Dichlorobenzidine's mechanism of toxicity derives mainly from the adduction of DNA by its metabolites. The formation of nitroso derivatives during metabolism, yielding a sulfinic acid amide with hemoglobin in erythrocytes, is suggested to be a mechanism for this adduct formation. 3,3’-Dichlorobenzidine can act on the aryl hydrocarbon receptor to induce the activity of cytochrome p-450 enzymes, which metabolize 3,3’-dichlorobenzidine, along with other polyhalogenated aromatics, into their toxic intermediates. (L124, A89, A90)
代谢
3,3'-Dichlorobenzidine is absorbed via ingestion, inhalation, and dermal routes. The major path of metabolism is believed to be N-acetylation via hepatic N-acetyltransferases, producing metabolites such as N-acetyl-3,3’-dichlorobenzidine and N,N-diacetyl-3,3’-dichlorobenzidine. 3,3'-Dichlorobenzidine may also be activated to toxic intermediates by certain cytochrome P-450 monooxygenases. Metabolites are excreted primarily in urine and to a lesser extent in faeces. (L124)
用途/来源
3,3'-Dichlorobenzidine is used in pigments for printing inks, textiles, plastics and enamels, paint, leather, and rubber. (L124)
症状
The salt form of 3,3'-dichlorobenzidine may cause sore throat, respiratory infections, stomach upset, headache, dizziness, caustic burns, and dermatitis. (L124)