毒素T3DB ID

T3D0040

目标BioDB ID

BE0000629

目标名称

Hemoglobin subunit beta

目标UniProt ID

P68871

作用机理

3,3鈥?Dichlorobenzidine`s mechanism of toxicity derivies mainly from the adduction of DNA by its metabolites. The formation of nitroso derivatives during metabolism, yielding a sulfinic acid amide with hemoglobin in erythrocytes, is suggested to be a mechanism for this adduct formation. (L124, A89)

参考文献

A89 - Sabbioni G, Schutze D: Hemoglobin binding of bicyclic aromatic amines. Chem Res Toxicol. 1998 May;11(5):471-83. (9585478) L124 - ATSDR - Agency for Toxic Substances and Disease Registry (1998). Toxicological profile for 3,3'-dichlorobenzidine. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). (http://www.atsdr.cdc.gov/toxprofiles/tp108.html)

创建于

2009-05-08 17:54:35 UTC

更新于

2014-09-04 15:56:23 UTC

目标详情