Trichloroethylene
SmallMolecule
T3DB_ID
T3D0016
描述
Trichloroethylene is a solvent and extractive in the manufacture of foods. One recent review of the epidemiology of kidney cancer rated cigarette smoking and obesity as more important risk factors for kidney cancer than exposure to solvents such as trichloroethylene. In contrast, the most recent overall assessment of human health risks associated with trichloroethylene states, [t]here is concordance between animal and human studies, which supports the conclusion that trichloroethylene is a potential kidney carcinogen. The evidence appears to be less certain at this time regarding the relationship between humans and liver cancer observed in mice, with the NAS suggesting that low-level exposure might not represent a significant liver cancer risk in the general population. The chemical compound trichloroethylene is a chlorinated hydrocarbon commonly used as an industrial solvent. It is a clear non-flammable liquid with a sweet smell. The first known report of TCE in groundwater was given in 1949 by two English public chemists who described two separate instances of well contamination by industrial releases of TCE. Based on available federal and state surveys, between 9% to 34% of the drinking water supply sources tested in the U.S. may have some TCE contamination, though EPA has reported that most water supplies are in compliance with the Maximum Contaminant Level (MCL) of 5 ppb. In addition, a growing concern in recent years at sites with TCE contamination in soil or groundwater has been vapor intrusion in buildings, which has resulted in indoor air exposures, such is in a recent case in the McCook Field Neighborhood of Dayton, Ohio. Trichloroethylene has been detected in 852 Superfund sites across the United States, according to the Agency for Toxic Substances and Disease Registry (ATSDR). Under the Safe Drinking Water Act of 1974, and as amended annual water quality testing is required for all public drinking water distributors. The EPA'S current guidelines for TCE can be found here. It should be noted that the EPA's table of TCE Releases to Ground is dated 1987 to 1993, thereby omitting one of the largest Superfund Cleanup sites in the nation, the NIBW in Scottsdale, Arizona. The TCE released here occurred prior to its appearance in the municipal drinking wells in 1982. This reaction can be catalyzed by a variety of substances. The most commonly used catalyst is a mixture of potassium chloride and aluminum chloride. However, various forms of porous carbon can also be used. This reaction produces tetrachloroethylene as a byproduct, and depending on the amount of chlorine fed to the reaction, tetrachloroethylene can even be the major product. Typically, trichloroethylene and tetrachloroethylene are collected together and then separated by distillation.Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity). Trichloroethylene is an effective solvent for a variety of organic materials.Trichloroethylene belongs to the family of Organochlorides. These are organic compounds containing a chlorine atom.
类别
"Cigarette Toxin", "Household Toxin", "Industrial/Workplace Toxin", "Pollutant", "Airborne Pollutant", "Food Toxin", "Synthetic Toxin"
同义词
"1,1,1-Trichloroethylene", "1,1,2-Trichloro-Ethene", "1,1,2-Trichloroethene", "1,1,2-Trichloroethylene", "1,1-Dichloro-2-chloroethylene", "1,2,2-Trichloroethylene", "1-Chloro-2,2-dichloroethylene", "Acetylene trichloride", "Algylen", "Altene DG", "Anamenth", "Benzinol", "Blacosolv", "Blancosolv", "C2HCl3", "Cecolene", "Chlorilen", "Chlorylea", "Chlorylen", "Chorylen", "Circosolv", "Crawhaspol", "Densi nfluat", "Densinfluat", "Disparit b", "Distillex DS2", "Dow-tri", "Dukeron", "Ethinyl trichloride", "Ethylene trichloride", "Fleck-flip", "Flock flip", "Fluate", "Gemalgene", "Germalgene", "Lanadin", "Lethurin", "Narcogen", "Narkogen", "Narkosoid", "Nialk", "Perm-a-chlor", "Perm-a-clor", "Petzinol", "Philex", "TCE", "Tce (chlorohydrocarbon)", "Threthylen", "Threthylene", "Trethylene", "TRI", "Tri-Clene", "Tri-plus", "Tri-plus m", "Triasol", "Tric hloroethene", "Trichlooretheen", "Trichloorethyleen, tri", "Trichloraethen", "Trichloraethylen", "Trichloran", "Trichlorathane", "Trichloren", "Trichlorethene", "Trichlorethylene", "Trichlorethylenum", "Trichloro-Ethene", "Trichloro-Ethylene", "Trichloroethene", "TrichloroetheneI", "Trichloroethylene (tce)", "Trichloroethylenum", "Trichlorothene", "Triciene", "Tricloretene", "Tricloroetilene", "Tricloroetileno", "Trielene", "Trielin", "Trielina", "Trieline", "Trik lone", "Triklone", "Triklone N", "Trilen", "Trilene", "Trilene TE-141", "Triline", "Trimar", "Triol", "Vestrol", "Vitran", "Westrosol"
CAS登记号
化学式
C2HCl3
平均分子量
131.388
单同位素质量
129.914383153
IUPAC 名称
1,1,2-trichloroethene
传统名称
trichloroethylene
简化分子线性输入规范
ClC=C(Cl)Cl
InChI 标识符
InChI=1S/C2HCl3/c3-1-2(4)5/h1H
InChIKey=XSTXAVWGXDQKEL-UHFFFAOYSA-N
化合物类型
Organic compounds
大分类
Organohalogen compounds
类型
Vinyl halides
子类
Vinyl chlorides
直接大类
Vinyl chlorides
另外分类
"Chloroalkenes", "Hydrocarbon derivatives", "Organochlorides"
取代基
"Aliphatic acyclic compound", "Chloroalkene", "Haloalkene", "Hydrocarbon derivative", "Organochloride", "Vinyl chloride"
分子框架
Aliphatic acyclic compounds
外部描述符
"a small molecule", "chloroethenes"
地位
Detected and Not Quantified
起源
Exogenous
蜂窝位置
"Cytoplasm", "Extracellular", "Membrane"
生物流体位置
组织位置
途径
状态
Liquid
外貌
Colorless liquid.
熔点/沸点/溶解度
-84.8°C/86.7°C (188.1°F)/1.28 mg/mL at 25°C
日志P
2.42
暴露途径
Oral (L14) ; inhalation (L14)
毒性机制
The toxic and carcinogenic effects of trichloroethylene are believed to be caused mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Dichloroacetic acid is known to inhibit pyruvate dehydrogenase kinase, while chloral hydrate inhibits alcohol dehydrogenase. Studies in rodents have shown that neurotoxic effects may be caused by trichloroethylene's incorporation into brain membranes or ability to alter the fatty acid pattern of brain phospholipids and amino acids. One of the mechanisms of trichloroethylene's carcinogenicity is believed to be the peroxisome proliferation induced by its metabolites. (L14, T12, A46)
代谢
Trichloroethylene is absorbed into the bloodstream and rapidly distributed throughout the body. Some is metabolized via cytochrome P-450 enzymes and the glutathione-conjugation pathway into metabolites such as trichloroacetic acid and trichloroethanol, which are excreted primarily in the urine. However, most trichoroethylene is exhaled unchanged or as carbon dioxide. (L15)
毒性值
LD50: 2402 mg/kg (Oral, Mouse) (T18) LD50: 20 001 mg/kg (Dermal, Rabbit) (T18) LD50: 3222 mg/kg (Intraperitoneal, Mouse) (T18)
致死剂量
3 to 5 mg/kg for an adult human. (L138)
致癌性
1, carcinogenic to humans. (L135)
用途/来源
Trichloroethylene is mainly used as an industrial solvent, particularily to remove grease from metal parts. It is also an ingredient in adhesives, paint removers, typewriter correction fluids, and spot removers. Exposure may result from contact with contaminated water. (L14)
最低风险等级
Acute Inhalation: 2 ppm (L134) Intermediate Inhalation: 0.1 ppm (L134) Acute Oral: 0.2 mg/kg/day (L134)
健康影响
Chronic inhalation or ingestion of tricholoethylene causes nerve, kidney, and liver damage, impaired immune system function, impaired fetal development in pregnant women, and possibly death. It has also been linked to both kidney and liver cancer. (L14)
症状
Inhalation of trichloroethylene causes headaches, lung irritation, dizziness, poor coordination, and difficulty concentrating, while ingestion results in nausea. Larger amounts may cause unconciousness and impaired heart function. Skin contact often results in rashes. (L14)
治疗
There is no known antidote for trichloroethylene. Exposure is usually handled with symptomatic treatment. (L15)
药库 ID
HMDB_ID
HMDB29593
PubChem 化合物 ID
6575
维基百科链接
http://en.wikipedia.org/wiki/Trichloroethylene
创建于
2009-03-06 18:57:55 UTC
更新于
2014-12-24 20:20:52 UTC
目标
毒素T3DB ID毒素名称目标名称
T3D0016 Trichloroethylene Estrogen receptor beta
T3D0016 Trichloroethylene Estrogen receptor alpha
T3D0016 Trichloroethylene Sodium/potassium-transporting ATPase subunit beta-3
T3D0016 Trichloroethylene Sodium/potassium-transporting ATPase subunit beta-2
T3D0016 Trichloroethylene Sodium/potassium-transporting ATPase subunit beta-1
T3D0016 Trichloroethylene Sodium/potassium-transporting ATPase subunit alpha-4
T3D0016 Trichloroethylene Sodium/potassium-transporting ATPase subunit alpha-3
T3D0016 Trichloroethylene Sodium/potassium-transporting ATPase subunit alpha-2
T3D0016 Trichloroethylene Sodium/potassium-transporting ATPase subunit alpha-1
T3D0016 Trichloroethylene Sodium/potassium-transporting ATPase subunit gamma
T3D0016 Trichloroethylene Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
T3D0016 Trichloroethylene Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
T3D0016 Trichloroethylene Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
T3D0016 Trichloroethylene Plasma membrane calcium-transporting ATPase 4
T3D0016 Trichloroethylene Plasma membrane calcium-transporting ATPase 3
T3D0016 Trichloroethylene Plasma membrane calcium-transporting ATPase 2
T3D0016 Trichloroethylene Plasma membrane calcium-transporting ATPase 1
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit theta
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit rho-3
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit rho-2
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit rho-1
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit pi
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit gamma-3
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit gamma-2
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit gamma-1
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit epsilon
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit delta
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit beta-3
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit beta-2
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit beta-1
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit alpha-6
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit alpha-5
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit alpha-4
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit alpha-3
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit alpha-2
T3D0016 Trichloroethylene Gamma-aminobutyric acid receptor subunit alpha-1
T3D0016 Trichloroethylene Calcium-transporting ATPase type 2C member 2
T3D0016 Trichloroethylene Calcium-transporting ATPase type 2C member 1
T3D0016 Trichloroethylene P2X purinoceptor 3
T3D0016 Trichloroethylene [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
T3D0016 Trichloroethylene [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial
T3D0016 Trichloroethylene Alcohol dehydrogenase 6
T3D0016 Trichloroethylene Alcohol dehydrogenase 4
T3D0016 Trichloroethylene Alcohol dehydrogenase class-3
T3D0016 Trichloroethylene Alcohol dehydrogenase class 4 mu/sigma chain
T3D0016 Trichloroethylene Alcohol dehydrogenase 1C
T3D0016 Trichloroethylene Alcohol dehydrogenase 1B
T3D0016 Trichloroethylene Alcohol dehydrogenase 1A
T3D0016 Trichloroethylene [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial
T3D0016 Trichloroethylene [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial

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