毒素T3DB ID

T3D0016

目标BioDB ID

BE0000227

目标名称

Alcohol dehydrogenase 1A

目标UniProt ID

P07327

作用机理

The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Chloral hydrate inhibits alcohol dehydrogenase. (A51)

参考文献

A51 - Sharkawi M, De Saint Blanquat G, Elfassy B: Inhibition of alcohol dehydrogenase by chloral hydrate and trichloroethanol: possible role in the chloral hydrate-ethanol interaction. Toxicol Lett. 1983 Jul;17(3-4):321-8. (6353674)

创建于

2009-04-14 21:08:36 UTC

更新于

2014-09-04 16:06:37 UTC

目标详情