毒素T3DB ID

T3D0016

目标BioDB ID

BE0004284

目标名称

[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial

目标UniProt ID

Q16654

作用机理

The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Dichloroacetic acid is known to inhibit pyruvate dehydrogenase kinase. (A50)

参考文献

A50 - Lantum HB, Baggs RB, Krenitsky DM, Anders MW: Nephrotoxicity of chlorofluoroacetic acid in rats. Toxicol Sci. 2002 Dec;70(2):261-8. (12441371)

创建于

2009-05-05 20:18:04 UTC

更新于

2014-09-04 16:13:33 UTC

目标详情