药物代谢和相互作用 121条(本栏目收费,不能显示细节,电话15274084725)
Utility of Genetically Modified Animal Models for Drug Metabolism and Drug Transporters
Introduction: An Overview of the Role of Metabolism in Drug Toxicity
Bioactivation I: Bioactivation by Cytochrome P450s
Bioactivation II: Phase I (Non-P450)
Bioactivation by Phase-II-Enzyme-Catalyzed Conjugation of Xenobiotics
Covalent Drug–Protein Adducts: An Exploration of Their Role in Drug-Induced Liver and General Organ Toxicity
Safety Testing of Drug Metabolites: A Practical Approach for the Implementation of the MIST Guidance in PKDM
In Vitro Toxicity Screening in Early Drug Discovery: Importance of Metabolism and Reactive Metabolites
The Application of Preclinical Toxicogenomics for Predicting and Understanding Drug-Induced Toxicity and Metabolism
Metabonomics in Understanding Drug Metabolism and Toxicology
Proteomics in Drug Discovery and Development
Stereochemical Elements Associated with Drug Metabolism and Toxicity
Genetics of Drug Disposition
Drug–Drug Interactions 1: Inhibition
Clinical Implications of CYP Induction-Mediated Drug–Drug Interactions
Age-Dependent Expression of Human Drug-Metabolizing Enzymes
Phytochemical Modulators of Human Drug Metabolism: Drug Interactions with Fruits, Vegetables, and Botanical Dietary Supplements
Idiosyncratic Drug Reactions
Animal Models of Idiosyncratic, Drug-Induced Liver Injury: Emphasis on the Inflammatory Stress Hypothesis
Regulation of Drug Metabolizing Enzymes and Transporters in Infection, Inflammation, and Cancer
Bioanalytical Support for Both In Vitro and In Vivo Assays Across Drug Discovery and Drug Development
General Principles of Mass Spectrometry: GC-MS, LC-MS, and LC-MS/MS
Infusion Nanoelectrospray Ionization Mass Spectrometry
A Perspective on the Evolving Field of Ambient Ionization Mass Spectrometry
Matrix-Assisted Laser Desorption/Ionization
Triple Quadrupole and Quadrupole Ion Trap Mass Spectrometers
Hybrid Mass Analyzers in Drug Metabolism Applications
Imaging Mass Spectrometry
Gas-Phase Ion Mobility-Mass Spectrometry (IM-MS) and Tandem IM-MS/MS Strategies for Metabolism Studies and Metabolomics
Inductively Coupled Plasma Mass Spectrometry for Analysis of Metal-Containing Pharmaceuticals