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 药物代谢和相互作用 121条(本栏目收费,不能显示细节,电话13136136841)
Review of Drug Metabolism in Drug Discovery and Development
In Vitro and In Vivo Models of Drug Metabolism
Enzyme Kinetics of Drug-Metabolizing Reactions and Drug−Drug Interactions
Sex Differences in Drug Metabolism
Species Differences of Drug-Metabolizing Enzymes
Structure and Function of Cytochrome P450 Enzymes
Mechanisms of Cytochrome P450-Mediated Reactions
Transcriptional Regulation of Cytochrome P450 Genes
Cytochrome P450 Polymorphisms
Flavin-Containing Monooxygenase: The Role of Flavin-Containing Monooxgenase in Lead Design and Selection
Molybdenum-Containing Hydroxylases
Amine Oxidases and Reductases
Epoxide Hydrolases
Carboxylesterases
UDP-Glucuronosyltransferases: Pharmacogenetics, Functional Characterization, and Clinical Relevance
Sulfotransferases
Functional Genomics of the Human Glutathione Transferases
Amino Acid Conjugation: A Novel Route of Xenobiotic Carboxylic Acid Metabolism in Man
ADME Profiling in Drug Discovery and Development: An Overview
Anatomical and Physiological Parameters that Influence Gastrointestinal Absorption
Oral Absorption: from Physiology to Regulatory
General Principles of Drug Distribution
ABC Drug Transporters and Their Impact on Drug Disposition/Drug Sensitivity and Resistance
Solute Carrier (SLC) Family Transporters
Mechanisms of Drug Metabolism
Extrahepatic Drug-Metabolizing Enzymes and Their Significance
Mass Balance Studies in Animals and Humans
Bioavailability and Bioequivalence
Interspecies Pharmacokinetic Scaling and the Prediction of Human Pharmacokinetics Using Animal and Cell Models
The Significance and Determination of Plasma Protein Binding

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