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药物代谢和相互作用 121条(本栏目收费,不能显示细节,电话13136136841)

Review of Drug Metabolism in Drug Discovery and Development

In Vitro and In Vivo Models of Drug Metabolism

Enzyme Kinetics of Drug-Metabolizing Reactions and Drug−Drug Interactions

Sex Differences in Drug Metabolism

Species Differences of Drug-Metabolizing Enzymes

Structure and Function of Cytochrome P450 Enzymes

Mechanisms of Cytochrome P450-Mediated Reactions

Transcriptional Regulation of Cytochrome P450 Genes

Cytochrome P450 Polymorphisms

Flavin-Containing Monooxygenase: The Role of Flavin-Containing Monooxgenase in Lead Design and Selection

Molybdenum-Containing Hydroxylases

Amine Oxidases and Reductases

Epoxide Hydrolases

Carboxylesterases

UDP-Glucuronosyltransferases: Pharmacogenetics, Functional Characterization, and Clinical Relevance

Sulfotransferases

Functional Genomics of the Human Glutathione Transferases

Amino Acid Conjugation: A Novel Route of Xenobiotic Carboxylic Acid Metabolism in Man

ADME Profiling in Drug Discovery and Development: An Overview

Anatomical and Physiological Parameters that Influence Gastrointestinal Absorption

Oral Absorption: from Physiology to Regulatory

General Principles of Drug Distribution

ABC Drug Transporters and Their Impact on Drug Disposition/Drug Sensitivity and Resistance

Solute Carrier (SLC) Family Transporters

Mechanisms of Drug Metabolism

Extrahepatic Drug-Metabolizing Enzymes and Their Significance

Mass Balance Studies in Animals and Humans

Bioavailability and Bioequivalence

Interspecies Pharmacokinetic Scaling and the Prediction of Human Pharmacokinetics Using Animal and Cell Models

The Significance and Determination of Plasma Protein Binding

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