药物发现,开发和制造 499条(本栏目收费,不能显示细节,电话15274084725)
REGULATORY CONSIDERATIONS 3641
REGULATORY ISSUES IN
PRECLINICAL SAFETY STUDIES
( U . S . FDA ) 3661
SELECTION AND UTILIZATION OF
CRO s FOR SAFETY ASSESSMENT 3675
AUDITING AND INSPECTING
PRECLINICAL RESEARCH AND
COMPLIANCE WITH GOOD
LABORATORY PRACTICE (GLP) 3689
DRUG IMPURITIES AND
DEGRADANTS AND THEIR
SAFETY QUALIFICATION 3711
BRIDGING STUDIES IN PRECLINICAL
PHARMACEUTICAL SAFETY
ASSESSMENT 3743
Historical Perspective 3749
Factors Affecting Metabolism 3759
Biotransformations in Drug
Metabolism 3763
In Vivo Metabolite Kinetics 3787
Pharmacogenetics and
Pharmacogenomics 3811
Introduction to Drug Transporters 3835
Automated Drug Screening for
ADMET Properties 3873
Approaches to Performing Metabolite
Elucidation: One Key to Success in
Drug Discovery and Development 3973
Structural Modifi cations of Drug
Candidates: How Useful Are They
in Improving Metabolic Stability of
New Drugs? Part I: Enhancing
Metabolic Stability 3997
Structural Modifi cations of Drug
Candidates: How Useful Are They in
Improving PK Parameters of New
Drugs? Part II : Drug Design Strategies 4013
Minimizing the Potential for Drug
Bioactivation of Drug Candidates to
Success in Clinical Development 4027
Screening for Reactive Metabolites
Using Genotoxicity Arrays and
Enzyme/ DNA Biocolloids 4051
Evaluating and Predicting Human
Cytochrome P450 Enzyme Induction 4101
An Introduction to Metabolic
Reaction Phenotyping 4133
Nuclear Receptor - Mediated Gene
Regulation in Drug Metabolism 4191
Characterization of Cytochrome P 450
Mechanism - Based Inhibition 4221
Clinical Drug – Drug Interactions 4277
Pharmaceutical Excipients in
Drug – Drug Interaction 4289
The Role of Drug Metabolism
in Toxicity 4301
Allergic Reactions to Drugs 4369
Chemical Mechanisms in Toxicology 4395
Mechanisms of Reproductive Toxicity 4437