药物发现,开发和制造

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药物发现,开发和制造 499条(本栏目收费,不能显示细节,电话13136136841)

REGULATORY CONSIDERATIONS 3641

REGULATORY ISSUES IN PRECLINICAL SAFETY STUDIES ( U . S . FDA ) 3661

SELECTION AND UTILIZATION OF CRO s FOR SAFETY ASSESSMENT 3675

AUDITING AND INSPECTING PRECLINICAL RESEARCH AND COMPLIANCE WITH GOOD LABORATORY PRACTICE (GLP) 3689

DRUG IMPURITIES AND DEGRADANTS AND THEIR SAFETY QUALIFICATION 3711

BRIDGING STUDIES IN PRECLINICAL PHARMACEUTICAL SAFETY ASSESSMENT 3743

Historical Perspective 3749

Factors Affecting Metabolism 3759

Biotransformations in Drug Metabolism 3763

In Vivo Metabolite Kinetics 3787

Pharmacogenetics and Pharmacogenomics 3811

Introduction to Drug Transporters 3835

Automated Drug Screening for ADMET Properties 3873

Mass Spectrometry 3911

Approaches to Performing Metabolite Elucidation: One Key to Success in Drug Discovery and Development 3973

Structural Modifi cations of Drug Candidates: How Useful Are They in Improving Metabolic Stability of New Drugs? Part I: Enhancing Metabolic Stability 3997

Structural Modifi cations of Drug Candidates: How Useful Are They in Improving PK Parameters of New Drugs? Part II : Drug Design Strategies 4013

Minimizing the Potential for Drug Bioactivation of Drug Candidates to Success in Clinical Development 4027

Screening for Reactive Metabolites Using Genotoxicity Arrays and Enzyme/ DNA Biocolloids 4051

Enzyme Inhibition 4085

Evaluating and Predicting Human Cytochrome P450 Enzyme Induction 4101

An Introduction to Metabolic Reaction Phenotyping 4133

Nuclear Receptor - Mediated Gene Regulation in Drug Metabolism 4191

Characterization of Cytochrome P 450 Mechanism - Based Inhibition 4221

Clinical Drug – Drug Interactions 4277

Pharmaceutical Excipients in Drug – Drug Interaction 4289

The Role of Drug Metabolism in Toxicity 4301

Allergic Reactions to Drugs 4369

Chemical Mechanisms in Toxicology 4395

Mechanisms of Reproductive Toxicity 4437

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