单克隆抗体应对最终药物的生产,配制,递送和稳定性方面的挑战 407条(本栏目收费,不能显示细节,电话15274084725)
water replacement,114 114
mAb1 electrostatic potential surface computation,181,182 182
linking amino acid sequence,182,185 185
nondissociable soluble aggregates of mAb1,181 181
overall dipole moment,182 182
reversible self-association of,175,176 176
mAb2 electrostatic potential surface computation,181,182 182
linking amino acid sequence,182,185 185
overall dipole moment,182 182
reversible self-association,175,176 176
Magnetic piston travel time of,167 167
Maillard reaction,115,117 117
Membrane-confined electrophoresis(MCE),24 24
Active pharmaceutical ingredient (API),1 1
Adsorption to surfaces,80 80
during bioprocessing,73 73
of mAb during long-term storage,73,75 75
of mAb during unit processing operations,75,77 77
protein aggregation,70,71 71
Aggregation-prone region (APR),105 105
Air/water interfaces exposure to,77,78 78
Analytical ultracentrifugation (AUC),29,30 30
Antibody drug conjugates (ADCs),193,194 194