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 单克隆抗体应对最终药物的生产,配制,递送和稳定性方面的挑战 407条(本栏目收费,不能显示细节,电话13136136841)
silicone oil interactions with proteins and mAbs,155,156 155 156 
viscous solutions delivery using,153,154 153 154 
primary container/closure systems,154,155 154 155 
silicone oil interactions with proteins and mAbs,155,156 155 156 
technical challenges for device and formulation development,154 154 
DepotOne®,153,154 153 154 
Di-2-ethylhexyl-phthalate (DEHP),121,122 121 122 
Diafiltration unit operations,78,79 78 79 
Differential scanning calorimetry (DSC),32,33,70,136 32 33 70 136 
Diffusion coefficient,169 169 
3;4-dihydroxyphenylalanine (DOPA),56,58 56 58 
Dityrosine,56,58 56 58 
Dosage form assessment—solid vs. liquid dosage forms,93,103 93 103 
Drug product (DP),2,139,140 2 139 140 
large-scale pumps in,78 78 
Drug substance (DS),2 2 
Drug antibody ratio (DAR),193,194 193 194 
Dynamic light scattering (DLS),32,168 32 168 
DLS interaction parameter,172,174 172 174 
Einstein’s equation,143,145 143 145 
Electrophoretic methods CE,23,24 23 24 
isoelectric focusing,22,23 22 23 
of TMVP and r-TMVP,23 23 
MCE,24 24 
native PAGE,22 22 
reduced and nonreduced sodium dodecyl sulfate electrophoresis,21,22 21 22 
Enhanze™,148,150 148 150 
Enzyme-linked immunosorbent assay(ELISA),36 36 
Epoetin® (EPO),159 159 
Erythropoietin (EPO),157 157 
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