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 单克隆抗体应对最终药物的生产,配制,递送和稳定性方面的挑战 407条(本栏目收费,不能显示细节,电话13136136841)
Heavy chains (HC),12,13 12 13 
Hemoglobin S (HbS),178,181 178 181 
High viscosity,132,134 132 134 
High-concentration mAb formulation analytical tools for,136 136 
bioavailability of,135,136 135 136 
High-concentration SC formulations alternative processes/formulations development,139,140 139 140 
analytical tools for development,136 136 
using existing manufacturing technologies,139,140 139 140 
using formulation excipients to reduce viscosity,146,150 146 150 
lyophilization of mAb,145 145 
manufacturing impact,134,135 134 135 
stability and final tonicity,143 143 
of IgG1 mAb,143 143 
High-performance liquid chromatography(HPLC),17 17 
Higher order structure,68,69 68 69 
Histidine oxidation,53,54 53 54 
in mAbs,54 54 
Horseradish peroxidase (HRP),36,37 36 37 
HRP. See Horseradish peroxidase human growth hormone (hGH),35 35 
Human hyaluronidase (rhuPH-20),148,150 148 150 
Hydrophobic bond,20,21 20 21 
Hydrophobic interaction chromatography(HIC),20,103 20 103 
In silico methods to assessing protein degradation routes,105 105 
In€vitro analytical based assay,36 36 
In€vivo animal based assay,35 35 
Inductively coupled plasma mass spectrometry (ICP-MS),157,159 157 159 
Infliximab,146 146 
Infrared spectroscopy (IR spectroscopy),28,29 28 29 
Insolubility,139 139 
Fc fusion and Fab conjugates,4,11 4 11 
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