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单克隆抗体应对最终药物的生产,配制,递送和稳定性方面的挑战 407条(本栏目收费,不能显示细节,电话13136136841)
Heavy chains (HC),12,13
12 13
Hemoglobin S (HbS),178,181
178 181
High viscosity,132,134
132 134
High-concentration mAb formulation analytical tools for,136
136
bioavailability of,135,136
135 136
High-concentration SC formulations alternative processes/formulations development,139,140
139 140
analytical tools for development,136
136
using existing manufacturing technologies,139,140
139 140
using formulation excipients to reduce viscosity,146,150
146 150
lyophilization of mAb,145
145
manufacturing impact,134,135
134 135
stability and final tonicity,143
143
High-performance liquid chromatography(HPLC),17
17
Higher order structure,68,69
68 69
Histidine oxidation,53,54
53 54
Horseradish peroxidase (HRP),36,37
36 37
HRP. See Horseradish peroxidase human growth hormone (hGH),35
35
Human hyaluronidase (rhuPH-20),148,150
148 150
Hydrophobic bond,20,21
20 21
Hydrophobic interaction chromatography(HIC),20,103
20 103
In silico methods to assessing protein degradation routes,105
105
In€vitro analytical based assay,36
36
In€vivo animal based assay,35
35
Inductively coupled plasma mass spectrometry (ICP-MS),157,159
157 159
Infrared spectroscopy (IR spectroscopy),28,29
28 29
Fc fusion and Fab conjugates,4,11
4 11