单克隆抗体应对最终药物的生产,配制,递送和稳定性方面的挑战 407条(本栏目收费,不能显示细节,电话13136136841)
Quartz crystal microbalance,168,171 171
recombinant human growth hormone(rhGH),69 69
Reversed phase chromatography(RP-HPLC),20,21 21
Rotational rheometers,166,167 167
SEC. See Size exclusion chromatography“Self-association” aggregation,71 71
Silicone oil interactions with proteins and mAbs,155,156 156
Site-specific oxidation,53,54 54
Size exclusion chromatography (SEC),17,18,103,135,136 136
Sodium dodecyl sulfate electrophoresis (SDS electrophoresis),21,22 22
reduced and nonreduced,21,22 22
Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS PAGE),60,62 62
Sodium polytungstate (Na6O39W12),159 159
Sodium tungstate dihydrate (Na2WO4·2H2O),159 159
Spectroscopic methods,24 24
fluorescence spectroscopy,28 28
ultraviolet absorption spectroscopy,24,25 25
SPR. See Surface plasmon resonance Stability,45 45
adsorption to surfaces,80 80
chemical and physical protein degradation,46 46
chemical degradation,45,51 51
degradation routes in mAbs,45 45
exposure to air/water interfaces,77,78 78
nonenzymatic peptide fragmentation,62,65 65
nonreducible cross-linking in mAbs,66,67 67