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单克隆抗体应对最终药物的生产,配制,递送和稳定性方面的挑战 407条(本栏目收费,不能显示细节,电话13136136841)
water replacement,114
114
mAb1 electrostatic potential surface computation,181,182
181 182
linking amino acid sequence,182,185
182 185
nondissociable soluble aggregates of mAb1,181
181
overall dipole moment,182
182
reversible self-association of,175,176
175 176
mAb2 electrostatic potential surface computation,181,182
181 182
linking amino acid sequence,182,185
182 185
overall dipole moment,182
182
reversible self-association,175,176
175 176
Magnetic piston travel time of,167
167
Maillard reaction,115,117
115 117
Membrane-confined electrophoresis(MCE),24
24
Active pharmaceutical ingredient (API),1
1
Adsorption to surfaces,80
80
during bioprocessing,73
73
of mAb during long-term storage,73,75
73 75
of mAb during unit processing operations,75,77
75 77
protein aggregation,70,71
70 71
Aggregation-prone region (APR),105
105
Air/water interfaces exposure to,77,78
77 78
Analytical ultracentrifugation (AUC),29,30
29 30
Antibody drug conjugates (ADCs),193,194
193 194