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单克隆抗体应对最终药物的生产,配制,递送和稳定性方面的挑战 407条(本栏目收费,不能显示细节,电话13136136841)
Microflow digital imaging (MDI),34
34
Microfluidic rheometry,167
167
Modified Mooney equation,171
171
Modulated DSC,32,33
32 33
aggregation and viscosity,178,181
178 181
analytical methods for evaluation biophysical methods,29,34
29 34
chromatographic methods,17,21
17 21
electrophoretic methods,21,24
21 24
methods to particulates evaluation,34
34
potency assays,35,37
35 37
spectroscopic methods,24,29
24 29
buffers for pH control,107
107
ionic strength,108,110
108 110
surface-active agents,110,111
110 111
tonicity modifiers,108,110
108 110
particulates evaluation methods in formulations,34
34
protein therapeutics mAbs as,3
3
protein/mAb stability,121,127
121 127
lyophilization formulation development,112,114
112 114
Protein protein interactions (PPI),139
139
net charge impact vs. localized surface charge distribution,178,179
178 179
aggregation and viscosity of mAbs,178,181
178 181
nondissociable soluble aggregates of mAb1,181
181
viscosity dependence on,171,175
171 175
Pure red cell aplasia (PRCA),157
157