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 抗衰老药物 648条(本栏目收费,不能显示细节,电话15274084725)
as clinical drug, 336–337 337
lifespan-extending effect in human subjects,332–333 333
in invertebrates, 329–331 331
in vertebrate, 331–332 332
molecular targets, 336 336
NAD+-dependent deacetylase sirtuin, 334–335 335
target molecules for, 333 333
resveratrol (3,5,4'-trihydroxystilbene),193 193
S-adenosylmethionine (SAM) and aging, 436–437 437
discovery of, 435 435
iron–sulfur (FeS) clusters discovery of, 444 444
Elp3, 447–448 448
radical SAM-binding 0
domain, 444–445 445
radical SAM 0
methylthiotransferases (MMTases), 447 447
radical SAM 0
methyltransferases (RSMT), 446–447 447
SAM radical enzymes,445–446 446
long-lived rodents, 450 450
microbiome and aging, 450–452 452
mitochondria and aging, 449 449
neurodegeneration, 449–450 450
riboswitches, 443–444 444
SAM-dependent enzymes cystathionine betasynthase (CBS), 442 442
glutathione, 442 442
methionine cycle,438–442 442
parts of, 437–438 438
polyamine pathway, 442 442
structures of, 438 438
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