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抗癌药物药物化学第二版 1849条(本栏目收费,不能显示细节,电话13136136841)
8.1. G-quadruplex ligands ..... 313
313
8.2. Inhibitors of telomerase reverse transcriptase ... 316
316
8.3. Inhibitors of the RNA domain template .... 316
316
EPIGENETIC THERAPY OF CANCER ...325
325
1. Introduction .....325
325
2. Inhibitors of DNA methylation: reactivation of silenced genes ...328
328
2.1. Nucleoside inhibitors of DNA methyltransferases .... 329
329
2.2. Non-nucleoside inhibitors of DNA methyltransferase ... 335
335
3. Inhibitors of histone and other protein deacetylases ...337
337
3.1. Short-chain fatty acids ..... 339
339
3.2. Hydroxamic acids .... 340
340
3.3. Cyclic tetrapeptides ..... 343
343
3.4. Benzamides ...... 345
345
3.5. Thiols ..... 345
345
3.6. Inhibitors of HDAC4 ..... 346
346
3.7. Inhibitors of sirtuins ..... 347
347
3.8. Bromodomain inhibitors ..... 348
348
4. Regulators of histone methylation .....350
350
4.1. Inhibitors of histone methyltransferases ... 351
351
4.2. Lysine-specific demethylases (LSDs or KDMs) and their inhibitors ... 353
353
References .......356
356
ANTICANCER DRUGS TARGETING TUBULIN AND MICROTUBULES ...359
359
1. Introduction .....359
359
2. Drugs that inhibit microtubule polymerization ....361
361
2.1. Compounds binding at the vinca site ... 361
361
2.1.1. Vinca alkaloids and their synthetic analogs .... 361
361
2.1.2. Marine natural products binding at the vinca domain and their analogs . 364
364
2.2. Compounds binding at the colchicine site .... 368
368
3. Microtubule-stabilizing agents: compounds binding at the taxane site ...373
373
3.1. Taxanes ...... 373
373