羟考酮,临床注释,变异和临床注释数据

羟考酮

临床注释ID

1451152827

药物名称(英)

oxycodone

变异单倍型

CYP2D6*1, CYP2D6*3, CYP2D6*4

基因

CYP2D6

证据级别

水平覆盖

水平修饰符

Tier 1 VIP

表现型类别(英)

Toxicity

表现型类别

毒性

分数

2.5

PMID计数

计数的证据

表现型

阿片类药物相关疾病

表现型(英)

Opioid-Related Disorders

最新日期

2021-04-23

URL

https://www.pharmgkb.org/clinicalAnnotation/1451152827

专业人口(英)

专业人口

临床等位基因

id	等位基因	注释文本
557	*3	Patients carrying the CYP2D63 allele in combination with another no function allele may be at a decreased risk of developing opioid dependence as a result of taking oxycodone as compared to patients carrying two normal function alleles or a normal function allele in combination with a no function allele. Patients carrying the 3 allele in combination with a normal function allele may be at an increased risk of developing opioid dependence as a result of taking oxycodone as compared to patients carrying two no function alleles. This drug-variant pair has been assigned a 鈥渘o recommendation鈥?by CPIC and DPWG, as it was determined to be not clinically actionable. Other genetic and clinical factors may also affect risk of developing opioid dependence.
556	*1	Patients carrying the CYP2D61 allele in combination with another normal function allele or a no function allele may be at an increased risk of developing opioid dependence as a result of taking oxycodone as compared to patients carrying two no function alleles. Patietns carrying the 1 allele in combination with a no function allele may be at a decreased risk of developing opioid dependence as a result of taking oxycodone as compared to patients carrying two normal function alleles. This drug-variant pair has been assigned a 鈥渘o recommendation鈥?by CPIC and DPWG, as it was determined to be not clinically actionable. Other genetic and clinical factors may also affect risk of developing opioid dependence.
277	*4	Patients carrying the CYP2D64 allele in combination with another no function allele may be at a decreased risk of developing opioid dependence as a result of taking oxycodone as compared to patients carrying two normal function alleles or a normal function allele in combination with a no function allele. Patients carrying the 4 allele in combination with a normal function allele may be at an increased risk of developing opioid dependence as a result of taking oxycodone as compared to patients carrying two no function alleles. This drug-variant pair has been assigned a 鈥渘o recommendation鈥?by CPIC and DPWG, as it was determined to be not clinically actionable. Other genetic and clinical factors may also affect risk of developing opioid dependence.

临床证据

id	证据的ID	总结
14541	1451152760	CYP2D6 3/3 + 4/4 are associated with decreased risk of Opioid-Related Disorders due to codeine, hydrocodone or oxycodone as compared to CYP2D6 1/1 + 1/3 + 1/4.

临床病史

id	类型	评论
21	Update	Edited phenotype descriptions
20	Update	CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
19	Create	Created

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