Patients carrying the CYP2D6*4 allele in combination with another no function allele may be at a decreased risk of developing opioid dependence as a result of taking oxycodone as compared to patients carrying two normal function alleles or a normal function allele in combination with a no function allele. Patients carrying the *4 allele in combination with a normal function allele may be at an increased risk of developing opioid dependence as a result of taking oxycodone as compared to patients carrying two no function alleles. This drug-variant pair has been assigned a 鈥渘o recommendation鈥?by CPIC and DPWG, as it was determined to be not clinically actionable. Other genetic and clinical factors may also affect risk of developing opioid dependence.