Patients carrying the CYP2D6*1 allele in combination with another normal function allele or a no function allele may be at an increased risk of developing opioid dependence as a result of taking oxycodone as compared to patients carrying two no function alleles. Patietns carrying the *1 allele in combination with a no function allele may be at a decreased risk of developing opioid dependence as a result of taking oxycodone as compared to patients carrying two normal function alleles. This drug-variant pair has been assigned a 鈥渘o recommendation鈥?by CPIC and DPWG, as it was determined to be not clinically actionable. Other genetic and clinical factors may also affect risk of developing opioid dependence.