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当前位置:药药网 / 数据中心 / 临床注释,变异和临床注释数据
利培酮
临床注释ID
1451151857
药物名称(英)
risperidone
变异单倍型
rs6313
基因
HTR2A
证据级别
3
水平覆盖
水平修饰符
表现型类别(英)
Efficacy
表现型类别
功效
分数
0.25
PMID计数
2
计数的证据
2
表现型
精神分裂症
表现型(英)
Schizophrenia
最新日期
2021-03-24
URL
https://www.pharmgkb.org/clinicalAnnotation/1451151857
专业人口(英)
专业人口
临床等位基因
id
等位基因
注释文本
381
GG
Patients with schizophrenia and the GG genotype may have a decreased response to risperidone as compared to patients with the AA or AG genotypes. However, this association was only found in a subanalysis of symptoms scores while another study failed to find an association. Other genetic and clinical factors may also affect a patient's response to risperidone.
380
AG
Patients with schizophrenia and the AG genotype may have an increased response to risperidone as compared to patients with the GG genotype but a decreased response as compared to patients with the AA genotype. However, this association was only found in a subanalysis of symptoms scores while another study failed to find an association. Other genetic and clinical factors may also affect a patient's response to risperidone.
379
AA
Patients with schizophrenia and the AA genotype may have an increased response to risperidone as compared to patients with the AG or GG genotypes. However, this association was only found in a subanalysis of symptoms scores while another study failed to find an association. Other genetic and clinical factors may also affect a patient's response to risperidone.
临床证据
id
证据的ID
总结
14429
1451151829
Genotypes AA + AG are associated with increased response to risperidone in people with Schizophrenia as compared to genotype GG.
1891
1450928304
Allele A is not associated with response to risperidone in people with Schizophrenia as compared to allele G.
临床病史
id
类型
评论
277
Create
Created
1
Update
CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
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