Dibutyl phthalate
描述
Dibutyl phthalate is found in cloves. DBP was added to the California Proposition 65 (1986) list of suspected teratogens in November 2006. It is a suspected endocrine disruptor. It was used in some nail polishes; all major producers began eliminating this chemical from nail polishes in the Fall of 2006. Dibutyl phthalate (DBP) is a commonly used plasticizer. It is also used as an additive to adhesives or printing inks. It is soluble in various organic solvents, e.g. in alcohol, ether and benzene. DBP is also used as an ectoparasiticide.
类别
"Household Toxin", "Industrial/Workplace Toxin", "Pollutant", "Airborne Pollutant", "Food Toxin", "Natural Toxin"
同义词
"1,2-Benzenedicarboxylic acid, 1,2-dibutyl ester", "1,2-Benzenedicarboxylic acid, dibutyl ester", "Araldite 502", "Benzene-O-dicarboxylic acid di-N-butyl ester", "Benzene-O-dicarboxylic acid, di-N-butyl ester", "Benzenedicarboxylic acid, dibutyl ester", "BUFA", "Butyl phthalate", "Butylphthalate", "Celluflex DPB", "DBP (ester)", "Di N butyl phthalate", "Di-N-butyl phthalate", "Di-N-butyl phthalate (dbup)", "Di-N-butylester kyseliny ftalove", "Di-N-butylorthophthalate", "di-N-butyphthalatel", "Dibutyl 1, 2-benzenedicarboxylate", "Dibutyl 1,2-benzenedicarboxylate", "Dibutyl ester of 1,2-benzenedicarboxylic acid", "Dibutyl O-phthalate", "Dibutyl phthalated", "Dibutyl phthalic acid", "Dibutyl-1,2-benzenedicarboxylate", "Dibutyl-O-phthalate", "Dibutyl-Phthalate", "Dibutyll phthalate", "Dibutylphthalate", "Dibutylphthatlate", "Elaol", "Ergoplast FDB", "Ersoplast fda", "Genoplast B", "Hatcol DBP", "Hexaplas m/b", "Kodaflex DBP", "Morflex 240", "N-Butyl phthalate", "N-Butylphthalate", "O-Benzenedicarboxylic acid, dibutyl ester", "Ortho-dibutyl phthalate", "Phthalic acid di-N-butyl ester", "Phthalic acid dibutyl ester", "Phthalic acid, dibutyl ester", "Polycizer DBP", "Rapidcelltrade markP", "RC plasticizer DBP", "Staflex DBP", "Uniflex DBP", "Unimoll DB", "Uniplex 150", "Witcizer 300"
IUPAC 名称
1,2-dibutyl benzene-1,2-dicarboxylate
简化分子线性输入规范
CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC
InChI 标识符
InChI=1S/C16H22O4/c1-3-5-11-19-15(17)13-9-7-8-10-14(13)16(18)20-12-6-4-2/h7-10H,3-6,11-12H2,1-2H3
键
InChIKey=DOIRQSBPFJWKBE-UHFFFAOYSA-N
类型
Benzene and substituted derivatives
子类
Benzoic acids and derivatives
另外分类
"Benzoyl derivatives", "Carboxylic acid esters", "Dicarboxylic acids and derivatives", "Hydrocarbon derivatives", "Organic oxides", "Organooxygen compounds"
取代基
"Aromatic homomonocyclic compound", "Benzoate ester", "Benzoyl", "Carboxylic acid derivative", "Carboxylic acid ester", "Dicarboxylic acid or derivatives", "Hydrocarbon derivative", "Organic oxide", "Organic oxygen compound", "Organooxygen compound"
分子框架
Aromatic homomonocyclic compounds
外部描述符
"Insect repellents", "Phthalates", "diester", "phthalate ester"
地位
Detected and Not Quantified
外貌
Colorless oily liquid.
熔点/沸点/溶解度
35°C/340 °C/0.0112 mg/mL at 25°C
暴露途径
Oral (L133) ; inhalation (L133) ; dermal (L133)
毒性机制
The most characteristic effect of di-n-butyl phthalate is testicular atrophy. Di-n-butyl phthalate exposure causes both the release of iron from hemoglobin and/or transferrin in the liver and spleen, and the subsequent depletion of iron in the blood and testes. The decreased amount of available iron results in a decrease in succinate dehydrogenase activity in the Sertoli cells. This results in disturbances in the energy transfer system between Sertoli cells and germ cells, which is required for the differentiation of male germ cells and their progression through the seminiferous epithelium and release as mature spermatozoa. Di-n-butyl phthalate may also exhibit weak estrogenic activity. It has been shown to exhibit toxic effects in liver mitochondria by uncoupling energy-linked processes and inhibiting succinate dehydrogenase. (L133, A105)
代谢
Di-n-butyl phthalate is absorbed via oral, inhalation, and dermal routes. It is rapidly distributed and cleared from the body. Metabolism of di-n-butyl phthalate proceeds mainly by nonspecific esterases in the gastrointestinal tract, which hydrolyze of one butyl ester bond to yield mono-n-butyl phthalate, the primary toxic metabolite. Mono-n-butyl phthalate is conjugated with glucuronic acid via glucuronosyltransferase and excreted in the urine. (L133)
毒性值
LD50: 3050 mg/kg (Intraperitoneal, Rat) (T13)
LD50: 720 mg/kg (Intravenous, Mouse) (T13)
LD50: 5289 mg/kg (Oral, Mouse) (T13)
LC50: 25 g/m3 over 2 hours (Inhalation, Mouse) (T13)
致癌性
No indication of carcinogenicity to humans (not listed by IARC).
用途/来源
Di-n-butyl phthalate is used to make plastics more flexible and is also in carpet backings, paints, glue, insect repellents, hair spray, nail polish, and rocket fuel. (L133)
健康影响
Adverse effects from di-n-butyl phthalate exposure have not yet been reported in humans. However, animals studies have shown that di-n-butyl phthalate can affect reproductive ability by decreasing sperm count and causing birth defects. (L133)
症状
Skin contact with di-n-butyl phthalate may cause mild irritation. (L133)
维基百科链接
http://en.wikipedia.org/wiki/Dibutyl_phthalate
创建于
2009-03-06 18:57:59 UTC
更新于
2014-12-24 20:20:59 UTC