毒素T3DB ID

T3D0052

目标BioDB ID

BE0000215

目标名称

Peroxisome proliferator-activated receptor gamma

目标UniProt ID

P37231

作用机理

Di-n-butyl phthalate causes peroxisome proliferation by activating peroxisome proliferator-activated receptors, which may lead to carcinogenic effects. (A106)

参考文献

A106 - Lapinskas PJ, Brown S, Leesnitzer LM, Blanchard S, Swanson C, Cattley RC, Corton JC: Role of PPARalpha in mediating the effects of phthalates and metabolites in the liver. Toxicology. 2005 Feb 1;207(1):149-63. (15590130) A9788 - Pereira-Fernandes A, Demaegdt H, Vandermeiren K, Hectors TL, Jorens PG, Blust R, Vanparys C: Evaluation of a screening system for obesogenic compounds: screening of endocrine disrupting compounds and evaluation of the PPAR dependency of the effect. PLoS One. 2013 Oct 14;8(10):e77481. doi: 10.1371/journal.pone.0077481. eCollection 2013. (24155963)

创建于

2009-05-15 15:44:43 UTC

更新于

2014-09-04 16:17:24 UTC

目标详情