Carbon monoxide
描述
Carbon monoxide, with the chemical formula CO, is a colorless, odorless, and tasteless gas. It is the product of the incomplete combustion of carbon-containing compounds, notably in internal-combustion engines. It consists of one carbon atom covalently bonded to one oxygen atom. It is a gas at room temperature. Carbon monoxide is a significantly toxic gas and is the most common type of fatal poisoning in many countries. Exposures can lead to significant toxicity of the central nervous system and heart. Carbon monoxide has a higher diffusion coefficient compared to oxygen and the only enzyme in the human body that produces carbon monoxide is heme oxygenase which is located in all cells and breaks down heme. Because it has a higher diffusion coefficient than oxygen the body easily gets rid of any CO made. When CO is not ventilated it binds to hemoglobin, which is the principal oxygen-carrying compound in blood; this produces a compound known as carboxyhemoglobin. The traditional belief is that carbon monoxide toxicity arises from the formation of carboxyhemoglobin, which decreases the oxygen-carrying capacity of the blood and inhibits the transport, delivery, and utilization of oxygen by the body. The affinity between hemoglobin and carbon monoxide is approximately 230 times stronger than the affinity between hemoglobin and oxygen so hemoglobin binds to carbon monoxide in preference to oxygen. Following poisoning, long-term sequelae often occur. Carbon monoxide can also have severe effects on the fetus of a pregnant woman. Despite its serious toxicity, CO is extremely useful and underpins much modern technology, being a precursor to a myriad of useful - even life-saving - products. Carbon monoxide, though thought of as a pollutant today, has always been present in the atmosphere, chiefly as a product of volcanic activity. It occurs dissolved in molten volcanic rock at high pressures in the earth's mantle. Carbon monoxide contents of volcanic gases vary from less than 0.01% to as much as 2% depending on the volcano. It also occurs naturally in bushfires. Because natural sources of carbon monoxide are so variable from year to year, it is extremely difficult to accurately measure natural emissions of the gas. (wikipedia).
类别
"Industrial/Workplace Toxin", "Pollutant", "Airborne Pollutant", "Food Toxin", "Natural Toxin"
同义词
"Carbon(II) oxide", "Carbonous oxide", "CO"
InChI 标识符
InChI=1S/CO/c1-2
键
InChIKey=UGFAIRIUMAVXCW-UHFFFAOYSA-N
化合物类型
Inorganic compounds
大分类
Homogeneous non-metal compounds
类型
Homogeneous other non-metal compounds
直接大类
Homogeneous other non-metal compounds
取代基
"Homogeneous other non metal"
外部描述符
"a small molecule", "carbon oxide", "one-carbon compound"
地位
Detected and Not Quantified
蜂窝位置
"Cytoplasm", "Extracellular", "Membrane"
熔点/沸点/溶解度
−205.02 °C/−191.5 °C/1.48 mg/mL at 25°C
毒性机制
Carbon monoxide possesses a higher affinity than oxygen for hemoglobin, leading to the formation of carboxyhemoglobin, this provoking anoxemia. Carbon monoxide also binds to myoglobin, impairing its ability to utilize oxygen. It can also bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. Carbon monoxide also causes endothelial cell and platelet release of nitric oxide, and the formation of oxygen free radicals. This results in lipid peroxidation, leading to edema and necrosis within the brain. (L961)
致死剂量
5000 ppm over 5 minutes for an adult human. (T26)
致癌性
No indication of carcinogenicity to humans (not listed by IARC).
用途/来源
Carbon monoxide is a major atmospheric pollutant in urban areas, chiefly from exhaust of internal combustion engines, but also from improper burning of various other fuels. (L960)
健康影响
Chronic exposure to low levels of carbon monoxide may cause persistent headaches, lightheadedness, depression, confusion, memory loss, and nausea and vomiting. (L961)
症状
Early symptoms of acute carbon monoxide poisoning are nonspecific and include headaches, nausea, and fatigue. Symptoms may progress to tachycardia and hypertension. The central nervous system is one of the organ systems most sensitive to poisoning and symptoms displayed include dizziness, ataxia, confusion, convulsions, unconsciousness, respiratory arrest, and even death. (L961)
治疗
Carbon monoxide poisoning is first treated by immediate removal from the source of exposure. High-flow or 100% oxygen should then be administered by a nonrebreather reservoir oxygen mask. Oxygen hastens the dissociation of carbon monoxide from hemoglobin, improving tissue oxygenation by reducing carbon monoxides biological half-life. Hyperbaric oxygen may also be used, as it increases carboxyhemoglobin dissociation to a greater extent than normal oxygen. (L961)
维基百科链接
http://en.wikipedia.org/wiki/Carbon monoxide
创建于
2009-03-06 18:58:15 UTC
更新于
2014-12-24 20:21:18 UTC
目标
| 毒素T3DB ID | 毒素名称 | 目标名称 |
|---|
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 8C, mitochondrial |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 8A, mitochondrial |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 7C, mitochondrial |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 7B2, mitochondrial |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 7B, mitochondrial |
| T3D0189 |
Carbon monoxide |
Putative cytochrome c oxidase subunit 7A3, mitochondrial |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 6C |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 6B2 |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 6B1 |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 6A2, mitochondrial |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 6A1, mitochondrial |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 5B, mitochondrial |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 5A, mitochondrial |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 3 |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 2 |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 1 |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 7A2, mitochondrial |
| T3D0189 |
Carbon monoxide |
Cytochrome c oxidase subunit 7A1, mitochondrial |
| T3D0189 |
Carbon monoxide |
Myoglobin |
| T3D0189 |
Carbon monoxide |
Hemoglobin subunit zeta |
| T3D0189 |
Carbon monoxide |
Hemoglobin subunit theta-1 |
| T3D0189 |
Carbon monoxide |
Hemoglobin subunit mu |
| T3D0189 |
Carbon monoxide |
Hemoglobin subunit gamma-2 |
| T3D0189 |
Carbon monoxide |
Hemoglobin subunit gamma-1 |
| T3D0189 |
Carbon monoxide |
Hemoglobin subunit epsilon |
| T3D0189 |
Carbon monoxide |
Hemoglobin subunit delta |
| T3D0189 |
Carbon monoxide |
Hemoglobin subunit beta |
| T3D0189 |
Carbon monoxide |
Hemoglobin subunit alpha |