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Tributyltin
目标名称
Proteasome subunit beta type-5
作用机理
Organotins inhibit the chymotrypsin-like activity of 20S and cellular proteasomes by binding to the beta-5 subunit. This results in apoptosis caused by downstream effects in the proteasome pathway. (A181)
参考文献
A181 - Shi G, Chen D, Zhai G, Chen MS, Cui QC, Zhou Q, He B, Dou QP, Jiang G: The proteasome is a molecular target of environmental toxic organotins. Environ Health Perspect. 2009 Mar;117(3):379-86. doi: 10.1289/ehp.11865. Epub 2008 Oct 23. (19337512)
创建于
2009-06-01 16:33:40 UTC
更新于
2014-09-04 16:18:56 UTC